Month: May 2022

Uncategorized Published - 19 May, 2022    By - Dr Clemens
A Neural Circuit from the Paraventricular Thalamus to the Bed Nucleus of the Stria Terminalis for the Regulation of States of Consciousness during Sevoflurane Anesthesia in Mice

Authors: Jia-Yan Li, M.D., Ph.D. et al  Anesthesiology May 2022, Vol. 136, 709–731. Background The neural circuitry underlying sevoflurane-induced modulation of consciousness is poorly understood. This study hypothesized that the paraventricular thalamus bed nucleus of the stria terminalis pathway plays an important role in regulating states of consciousness during sevoflurane anesthesia. Methods Rabies virus–based transsynaptic tracing […]

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Uncategorized Published - 18 May, 2022    By - Dr Clemens
General Anesthesia versus Sedation, Both with Hemodynamic Control, during Intraarterial Treatment for Stroke

Authors: Axelle Maurice, M.D.et al  Anesthesiology April 2022, Vol. 136, 567–576. Background It is speculated that the anesthetic strategy during endovascular therapy for stroke may have an impact on the outcome of the patients. The authors hypothesized that conscious sedation is associated with a better functional outcome 3 months after endovascular therapy for the treatment of […]

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Uncategorized Published - 18 May, 2022    By - Dr Clemens
Limiting Oral Intake during Labor: Do We Have It Right?

Authors:Craig M. Palmer, M.D. and Yandong Jiang, M.D., Ph.D. Anesthesiology April 2022, Vol. 136, 528–530. “Is it time to rethink our current recommendations on oral intake during labor and delivery?” Limiting oral intake during labor is part of our standard orders for most parturients admitted to labor and delivery suites, but what exactly is the science that […]

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Uncategorized Published - 18 May, 2022    By - Dr Clemens
Basal Infusion versus Automated Boluses and a Delayed Start Timer for “Continuous” Sciatic Nerve Blocks after Ambulatory Foot and Ankle Surgery

Authors: John J. Finneran, IV, M.D. et al  Anesthesiology June 2022, Vol. 136, 970–982. Background The common technique using a basal infusion for an ambulatory continuous peripheral nerve blocks frequently results in exhaustion of the local anesthetic reservoir before resolution of surgical pain. This study was designed to improve and prolong analgesia by delaying initiation using […]

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Uncategorized Published - 18 May, 2022    By - Dr Clemens
Prophylactic Penehyclidine Inhalation for Prevention of Postoperative Pulmonary Complications in High-risk Patients

Authors: Ting Yan, M.D. et al  Anesthesiology April 2022, Vol. 136, 551–566. Background Postoperative pulmonary complications are common. Aging and respiratory disease provoke airway hyperresponsiveness, high-risk surgery induces diaphragmatic dysfunction, and general anesthesia contributes to atelectasis and peripheral airway injury. This study therefore tested the hypothesis that inhalation of penehyclidine, a long-acting muscarinic antagonist, reduces the […]

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Uncategorized Published - 18 May, 2022    By - Dr Clemens
Viscoelastic Hemostatic Assays and Trauma: Are You Ready?

Authors: Thomas E. Grissom, MD, MSIS, FASA, FCCM and Kevin P. Blaine, MD, MPH, FASA ASA Monitor March 2022, Vol. 86, 29–30. Uncontrolled hemorrhage requiring emergent surgery after major trauma continues to be a contributor to perioperative death (Intensive Care Med 2019;45:709-11). While most hemorrhage deaths occur before injured patients reach the hospital, advancement in medical management […]

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Uncategorized Published - 17 May, 2022    By - Dr Clemens
Patient Sex and Postoperative Outcomes after Inpatient Intraabdominal Surgery

Authors: Jennifer W. He, B.MSc. et al  Anesthesiology April 2022, Vol. 136, 577–587. Background Intraabdominal surgeries are frequently performed procedures that lead to a high volume of unplanned readmissions and postoperative complications. Patient sex may be a determinant of adverse outcomes in this population, possibly due to differences in biology or care delivery, but it is […]

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Uncategorized Published - 17 May, 2022    By - Dr Clemens
Frequency and Risk Factors for Difficult Intubation in Women Undergoing General Anesthesia for Cesarean Delivery

Authors: Sharon C. Reale, M.D. et al  Anesthesiology May 2022, Vol. 136, 697–708. Background Estimates for the incidence of difficult intubation in the obstetric population vary widely, although previous studies reporting rates of difficult intubation in obstetrics are older and limited by smaller samples. The goals of this study were to provide a contemporary estimate of […]

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Uncategorized Published - 17 May, 2022    By - Dr Clemens
Intraoperative Hypotension and Acute Kidney Injury, Stroke, and Mortality during and outside Cardiopulmonary Bypass

Authors: Miguel Armengol de la Hoz, M.S. et al  Anesthesiology June 2022, Vol. 136, 927–939. Background In cardiac surgery, the association between hypotension during specific intraoperative phases or vasopressor-inotropes with adverse outcomes remains unclear. This study’s hypothesis was that intraoperative hypotension duration throughout the surgery or when separated into hypotension during and outside cardiopulmonary bypass […]

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Uncategorized Published - 17 May, 2022    By - Dr Clemens
Self-reported Race/Ethnicity and Intraoperative Occult Hypoxemia

Authors: Garrett W. Burnett, M.D. et al  Anesthesiology May 2022, Vol. 136, 688–696. Background Pulse oximetry is ubiquitous in anesthesia and is generally a reliable noninvasive measure of arterial oxygen saturation. Concerns regarding the impact of skin pigmentation and race/ethnicity on the accuracy of pulse oximeter accuracy exist. The authors hypothesized a greater prevalence of occult […]

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