Month: April 2022

Uncategorized Published - 27 April, 2022    By - Dr Clemens
Effectiveness of physiotherapy interventions for back care and the prevention of non-specific low back pain in children and adolescents

DG Journal Club AUTHORS: JosC) Manuel GarcC-a-Moreno et al BMC Musculoskelet Disord. 2022 Apr 2; 23(1): 314 BACKGROUND Non-specific low back pain in children and adolescents has increased in recent years. The purpose of this study was to upgrade the evidence of the most effective preventive physiotherapy interventions to improve back care in children and […]

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Uncategorized Published - 27 April, 2022    By - Dr Clemens
Central Venous-to-Arterial CO2 Difference–Assisted Goal-Directed Hemodynamic Management During Major Surgery

AUTHORS: H N, Lohith Kumar MD et al Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 1010-1020 BACKGROUND:  Different goals have guided goal-directed therapy (GDT). Protocols aiming for central venous-to-arterial carbon dioxide gap (DCO2) <6 mm Hg have improved organ function in septic shock. Evidence for use of DCO2 in the perioperative […]

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Uncategorized Published - 27 April, 2022    By - Dr Clemens
The Association Between Angiotensin II and Renin Kinetics in Patients After Cardiac Surgery

AUTHORS: Meersch, Melanie MD et al Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 1002-1009 BACKGROUND:  Hyperreninemia after cardiac surgery is associated with cardiovascular instability. Angiotensin II (AT-II) could potentially attenuate hyperreninemia while maintaining target blood pressure. This study assesses the association between AT-II usage and renin levels in cardiac surgery […]

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Uncategorized Published - 27 April, 2022    By - Dr Clemens
Chronic Pain Following Fracture-Related Surgery: Posttraumatic Rather Than Postsurgical Origin Promotes Chronification—A Prospective Observational Study With 1-Year Follow-up

AUTHORS: Aulenkamp, Jana L. MD et al  Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 974-986 BACKGROUND: Chronic posttraumatic/postsurgical pain (CPSP) is common after traumatic or surgical damage. Exposure to both trauma and surgery, with the potential for repeated bone and nerve damage, may increase the risk of CPSP after fracture-related […]

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Uncategorized Published - 27 April, 2022    By - Dr Clemens
Effectiveness of Perioperative Opioid Educational Initiatives

AUTHORS: Zorrilla-Vaca, Andres MD et al Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 940-951 BACKGROUND:  Opioids are the most commonly prescribed analgesics in the United States. Current guidelines have proposed education initiatives to reduce the risk of chronic opioid consumption, yet there is lack of efficacy data on such interventions. […]

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Uncategorized Published - 26 April, 2022    By - Dr Clemens
Antifibrinolytic Drugs for the Prevention of Bleeding in Pediatric Cardiac Surgery on Cardiopulmonary Bypass

AUTHORS: Siemens, Kristina MD et al  Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 987-1001 BACKGROUND:  Bleeding is one of the commonest complications affecting children undergoing cardiac surgery on cardiopulmonary bypass. Antifibrinolytic drugs are part of a multifaceted approach aimed at reducing bleeding, though sufficiently sized pediatric studies are sparse, and […]

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Uncategorized Published - 26 April, 2022    By - Dr Clemens
Control of Postoperative Hypotension Using a Closed-Loop System for Norepinephrine Infusion in Patients After Cardiac Surgery

AUTHORS: Desebbe, Olivier MD et al  Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 964-973 BACKGROUND: Vasopressors are a cornerstone for the management of vasodilatory hypotension. Vasopressor infusions are currently adjusted manually to achieve a predefined arterial pressure target. We have developed a closed-loop vasopressor (CLV) controller to help correct hypotension […]

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Uncategorized Published - 26 April, 2022    By - Dr Clemens
Prevalence and Outcomes of Opioid Use Disorder in Pediatric Surgical Patients

AUTHORS: Alalade, Emmanuel MD et al Anesthesia & Analgesia: April 2022 BACKGROUND: Chronic opioid use among adolescents is a leading preventable public health problem in the United States. Consequently, a sizable proportion of surgical patients in this age group may have a comorbid opioid use disorder (OUD). No previously published study has examined the prevalence of […]

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Uncategorized Published - 26 April, 2022    By - Dr Clemens
Brain-based measures of nociception during general anesthesia with remifentanil

DG Journal Club AUTHORS: Keerthana Deepti Karunakaran et al PLoS Med. 2022 Apr 22; 19(4): e1003965 BACKGROUND Catheter radiofrequency (RF) ablation for cardiac arrhythmias is a painful procedure. Prior work using functional near-infrared spectroscopy (fNIRS) in patients under general anesthesia has indicated that ablation results in activity in pain-related cortical regions, presumably due to inadequate […]

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Uncategorized Published - 26 April, 2022    By - Dr Clemens
Migraine and genetics: Largest study to date may inspire new treatments

Author: James Kingsland MedicalNewsToday Migraine is a condition that causes a pulsating or throbbing headache, usually on one side of the head. The headache often accompanies other symptoms, such as nausea, hypersensitivity to light and sound, and vomiting. A single episode can last several days with severe cases affecting a person’s ability to work or study. […]

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