Month: March 2022

Uncategorized Published - 9 March, 2022    By - Dr Clemens
Clonidine Versus Midazolam Premedication and Postoperative Negative Behavioral Changes in Younger Children

AUTHORS: Zickerman, Caroline MD et al Anesthesia & Analgesia: February 2022 BACKGROUND: Postoperative negative behavioral changes (NBCs) are common among children, but risk for this is thought to be reduced with premedication. Midazolam has for many years been a standard premedication for children. More recently, the alpha-2 adrenergic agonist clonidine has also become popular as a […]

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Uncategorized Published - 9 March, 2022    By - Dr Clemens
Population Pharmacokinetic Model for Tramadol and O-desmethyltramadol in Older Patients

DG Journal Club AUTHORS: Aymen A Al-Qurain, Richard N Upton et al. Eur J Drug Metab Pharmacokinet. 2022 Feb BACKGROUND AND OBJECTIVES Tramadol is commonly prescribed to manage chronic pain in older patients. However, there is a gap in the literature describing the pharmacokinetic parameters for tramadol and its active metabolite (O-desmethyltramadol [ODT]) in this […]

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Uncategorized Published - 9 March, 2022    By - Dr Clemens
Study finds link between chronic pain and disrupted eating

Author: Annie Lennon MedicalNewsToday Researchers investigated how lower back pain interacts with eating behavior via behavioral and neuroimaging experiments. They found that pain alters food satiety in those who have chronic lower back pain and those who have recovered from subacute back pain. Further studies are necessary to understand the mechanisms behind their results. Studies […]

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Uncategorized Published - 8 March, 2022    By - Dr Clemens
Use of Epidural in Childbirth Is Linked to Decreased Severe Maternal Morbidity

DG News In a study of vaginal births in New York State hospitals, labour neuraxial analgesia  was associated with a decreased risk of severe maternal morbidity. Deliveries with a neuraxial analgesia also lessened the risk of postpartum haemorrhage, the leading cause of preventable severe maternal morbidity, according to Jean Guglielminotti, MD, Columbia University Mailman School […]

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Uncategorized Published - 8 March, 2022    By - Dr Clemens
Early Vasopressor Utilization Strategies and Outcomes in Critically Ill Patients With Severe Traumatic Brain Injury

AUTHORS: Toro, Camilo BA et al Anesthesia & Analgesia: February 2022 BACKGROUND: Early hypotension after severe traumatic brain injury (sTBI) is associated with increased mortality and poor long-term outcomes. Current guidelines suggest the use of intravenous vasopressors, commonly norepinephrine and phenylephrine, to support blood pressure after TBI. However, guidelines do not specify vasopressor type, resulting in […]

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Uncategorized Published - 8 March, 2022    By - Dr Clemens
Association Between Perioperative Medication Use and Postoperative Delirium and Cognition in Older Adults Undergoing Elective Noncardiac Surgery

AUTHORS: Duprey, Matthew S. PharmD, PhD et al Anesthesia & Analgesia: February 2022 BACKGROUND: Postoperative delirium is frequent in older adults and is associated with postoperative neurocognitive disorder (PND). Studies evaluating perioperative medication use and delirium have generally evaluated medications in aggregate and been poorly controlled; the association between perioperative medication use and PND remains unclear. […]

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Uncategorized Published - 8 March, 2022    By - Dr Clemens
Efficacy and safety of transcutaneous electrical nerve stimulation (TENS) for acute and chronic pain in adults

AUTHORS: Mark I Johnson, Carole A Paley et al. BMJ Open. 2022 Feb 10 OBJECTIVE To investigate the efficacy and safety of transcutaneous electrical nerve stimulation (TENS) for relief of pain in adults. DESIGN Systematic review and meta-analysis. DATA SOURCES Medline, Cochrane Central, Embase (and others) from inception to July 2019 and updated on 17 […]

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Uncategorized Published - 8 March, 2022    By - Dr Clemens
What to know about high potassium

Author: Adrienne Stinson MedicalNewsToday Hyperkalemia is the medical term for when a person has higher than normal levels of potassium. Usually, people with hyperkalemia do not have any symptoms, which makes it challenging for a doctor to diagnose. The leading causes of hyperkalemia are chronic kidney disease, uncontrolled diabetes, dehydration, an injury causing severe bleeding, consuming excessive dietary potassium, and some […]

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Uncategorized Published - 7 March, 2022    By - Dr Clemens
The analgesic efficacy of transversus abdominis plane block vs. wound infiltration after inguinal and infra-umbilical hernia repairs

DG Journal Club AUTHORS: Sina Grape, Kyle R Kirkham et al. Eur J Anaesthesiol. 2022 Feb BACKGROUND Both transversus abdominis plane (TAP) block and wound infiltration with local anaesthetic have been used to relieve pain after inguinal or infra-umbilical hernia repair. OBJECTIVES To determine whether TAP block or local anaesthetic infiltration is the best analgesic […]

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Uncategorized Published - 7 March, 2022    By - Dr Clemens
Pediatric spinal anesthesia at a tertiary care hospital: Eleven years after Spinal anesthesia at a single institution

AUTHORS: RamC3n Eizaga Rebollar, MarC-a Victoria GarcC-a Palacios et al. Paediatr Anaesth. 2022 Feb BACKGROUND Pediatric spinal anesthesia is an old technique whose use is not widespread, in spite of reducing the risk of cardiorespiratory events (hypoxemia, bradycardia, and hypotension) associated with general anesthesia, especially in neonates and infants. This retrospective cohort study aimed to […]

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