AUTHORS: Hooten, W. Michael MD et al Anesthesia & Analgesia: June 2021 BACKGROUND: The adenosine triphosphate-binding cassette, subfamily B, member 1 gene (ABCB1) encodes P-glycoprotein (P-gp) that influences the intracellular transport of solutes including endogenous opioid peptides. The primary objective of this study was to determine the effects of the ABCB1 polymorphism c.3435C>T (rs10454642) on heat pain (HP) […]
Read MoreDG Journal Club AUTHORS: Johanna Margaretha Kroese, Sigvard Kopp et al. Clin Rheumatol. 2021 Jul 21 OBJECTIVES To evaluate the effect of corticosteroid injections in the painful temporomandibular joint (TMJ) of patients with rheumatoid arthritis (RA) in relation to systemic inflammatory activity. METHOD Examination of 35 patients (median age 54 years; 89% female) included maximum mouth […]
Read MoreAUTHORS: Kim, Hyunzu MD, PhD et al Anesthesia & Analgesia: June 2021 BACKGROUND: Relative to interscalene block, superior trunk block (STB) provides comparable analgesia and a reduced risk of hemidiaphragmatic paralysis. However, the incidence of hemidiaphragmatic paralysis remains high when a standard volume (15 mL) of local anesthetic is used. This study aimed to evaluate the […]
Read MoreAUTHORS: Xuan, Chengluan MD, PhD et al Anesthesia & Analgesia: June 2021 BACKGROUND: Peripheral nerve block (PNB) with perineural local anesthetic is used for anesthesia or analgesia with many benefits. To extend these benefits, various adjuvant drugs have been used to prolong the duration of analgesia. We aimed to evaluate the effectiveness of various adjuvants at […]
Read MoreAUTHORS: Verwijmeren, Lisa MD, PhD et al Anesthesia & Analgesia: June 2021 BACKGROUND: Acute kidney injury (AKI) is associated with mortality after cardiac surgery. Novel risk factors may improve identification of patients at risk for renal injury. The authors evaluated the association between preoperative biomarkers that reflect cardiac, inflammatory, renal, and metabolic disorders and cardiac surgery–associated […]
Read MoreAUTHORS: Bonvicini, Daniele MD et al Anesthesia & Analgesia: July 2021 BACKGROUND: Breast cancer is the most common malignancy in women. Surgery is a mainstay therapy unfortunately burdened by complications as severe postoperative pain. Regional anesthesia may play a role in a multimodal strategy for prevention and treatment of postoperative pain. The main purpose of this […]
Read MoreAuthor: Anthony Vecchione Cardiovascular Business Heart disease and stroke still rank among the leading causes of death in the United States, according to new CDC data. As one might expect, COVID-19 landed near the top of that list as well. Heart disease is currently the No. 1 cause of death in the United States. COVID-19 […]
Read MoreAUTHORS: Stundner, Ottokar MD, MBA et al Anesthesia & Analgesia: June 2021 BACKGROUND: An increasing body of evidence demonstrates an association between obstructive sleep apnea (OSA) and adverse perioperative outcomes. However, large-scale data on open colectomies are lacking. Moreover, the interaction of obesity with OSA is unknown. This study examines the impact of OSA, obesity, or […]
Read MoreDG Journal Club AUTHORS: Syed Hamza Mufarrih, Nada Qaisar Qureshi et al. Eur J Vasc Endovasc Surg. 2021 Jul 21 OBJECTIVE Primary and secondary lower extremity amputation, performed for patients with lower extremity arterial disease, is associated with increased post-operative morbidity. The aim of the study was to assess the impact of regional anaesthesia vs. […]
Read MoreAUTHORS: Lee, Allison MD, MS et al Anesthesia & Analgesia: June 2021 BACKGROUND: Cervical cerclage is a short ambulatory procedure. For spinal anesthesia, local anesthetic agents with rapid postoperative resolution are desired. We hypothesized that in combination with fentanyl, intrathecal 2-chloroprocaine would produce earlier resolution of motor block, resulting in shorter time to meet recovery room […]
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