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Authors: Ya-Wei Li, M.D. et al Anesthesiology June 2021. Background Delirium is a common and serious postoperative complication, especially in the elderly. Epidural anesthesia may reduce delirium by improving analgesia, reducing opioid consumption, and blunting stress response to surgery. This trial therefore tested the hypothesis that combined epidural–general anesthesia reduces the incidence of postoperative delirium […]
Read MoreAuthors: Veena Graff, M.D. et al Anesthesiology July 2021, Vol. 135, 111–121. Background Calls to better involve patients in decisions about anesthesia—e.g., through shared decision-making—are intensifying. However, several features of anesthesia consultation make it unclear how patients should participate in decisions. Evaluating the feasibility and desirability of carrying out shared decision-making in anesthesia requires better […]
Read MoreAuthor: Keith M. Vogt, M.D., Ph.D. et al Anesthesiology July 2021, Vol. 135, 69–82. Background Despite the well-known clinical effects of midazolam and ketamine, including sedation and memory impairment, the neural mechanisms of these distinct drugs in humans are incompletely understood. The authors hypothesized that both drugs would decrease recollection memory, task-related brain activity, and […]
Read MoreAuthors: Stephen C. Haskins, M.D. et al Anesthesiology June 2021. Background Hip arthroscopy is associated with moderate to severe postoperative pain. This prospective, randomized, double-blinded study investigates the clinically analgesic effect of anterior quadratus lumborum block with multimodal analgesia compared to multimodal analgesia alone. The authors hypothesized that an anterior quadratus lumborum block with multimodal […]
Read MoreBy Gerard Limerick, MD, PhD and Tina L. Doshi, MD, MHS Practical Pain Management Volume 21 Issue 3 The new class of CGRPs may also benefit patients living with chronic pain from trigeminal neuralgia, temporomandibular disorders, diabetic peripheral neuropathy, chemotherapy-induced neuropathy, and fibromyalgia. A review of the data to date. Calcitonin gene-related peptide (CGRP) antagonists have been a […]
Read MoreAuthors: Meg E. Carley, B.Sc. et al Anesthesiology June 2021. Background Chronic postsurgical pain can severely impair patient health and quality of life. This systematic review update evaluated the effectiveness of systemic drugs to prevent chronic postsurgical pain. Methods The authors included double-blind, placebo-controlled, randomized controlled trials including adults that evaluated perioperative systemic drugs. Studies […]
Read MoreAuthors: Jason Chui, M.B.Ch.B., M.Sc., F.A.N.Z.C.A., F.H.K.C.A., F.H.K.A.M. et al Anesthesiology July 2021, Vol. 135, 83–94. Background Evoked potential monitoring is believed to prevent neurologic injury in various surgical settings; however, its clinical effect has not been scrutinized. It was hypothesized that an automated nerve monitor can minimize intraoperative nerve injury and thereby improve clinical […]
Read MoreAuthor: Amanda Gerberich, PharmD, BCPS Practical Pain Management Volume 21 Issue 3 Hemophilia is a chromosomal disorder affecting coagulation that is characterized by spontaneous bleeding.1 The disorder affects approximately 1 in every 5,000 males. Hemophilia can be classified as a deficiency in clotting factor VIII (ie, hemophilia A), which is more common, or as a deficiency in […]
Read MoreAuthors: Huiping Ding, Ph.D. et al Anesthesiology June 2021. doi: Background Cebranopadol, a mixed nociceptin/opioid receptor full agonist, can effectively relieve pain in rodents and humans. However, it is unclear to what degree different opioid receptor subtypes contribute to its antinociception and whether cebranopadol lacks acute opioid-associated side effects in primates. The authors hypothesized that […]
Read MoreAuthor: Christine Rhodes, MS Practical Pain Management Volu 21 Issue 3 Acupuncture has been used for more than 2,000 years throughout Asia and is an important component of Traditional Chinese Medicine (TCM). Based on the concept of qi – the vital energy in the body that flows along well-defined meridians, acupuncture is thought to restore […]
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