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AUTHORS: Neff, Thomas A. MD et al Anesthesia & Analgesia: June 16, 2021 BACKGROUND: Postoperative complications in surgery are a significant burden, not only for the patients but also economically. While several predicting factors have already been identified, it is still not well known if increased levels of inflammatory markers in the immediate perioperative phase correlate […]
Read MoreAUTHORS: Zhang, Chengmi MD, PhD et al Anesthesia & Analgesia: June 11, 2021 BACKGROUND: The optimal positive end-expiratory pressure (PEEP) to prevent postoperative pulmonary complications (PPCs) remains unclear. Recent evidence showed that driving pressure was closely related to PPCs. In this study, we tested the hypothesis that an individualized PEEP guided by minimum driving pressure during […]
Read MoreAUTHORS: Zorrilla-Vaca, Andres MD et al Anesthesia & Analgesia: June 11, 2021 BACKGROUND: Opioids are the most commonly prescribed analgesics in the United States. Current guidelines have proposed education initiatives to reduce the risk of chronic opioid consumption, yet there is lack of efficacy data on such interventions. Our study evaluates the impact of perioperative opioid […]
Read MoreAUTHORS: Hooten, W. Michael MD et al Anesthesia & Analgesia: June 21, 2021 BACKGROUND: The adenosine triphosphate-binding cassette, subfamily B, member 1 gene (ABCB1) encodes P-glycoprotein (P-gp) that influences the intracellular transport of solutes including endogenous opioid peptides. The primary objective of this study was to determine the effects of the ABCB1 polymorphism c.3435C>T (rs10454642) on heat pain […]
Read MoreAUTHORS: Kouz, Karim MD et al Anesthesia & Analgesia: June 9, 2021 – BACKGROUND: It remains unknown what constitutes physiologically relevant intraoperative bradycardia. Intraoperative bradycardia is usually defined using absolute heart rate thresholds, ignoring preoperative baseline heart rates. In contrast, we considered defining intraoperative bradycardia relative to preoperative ambulatory nighttime heart rate. Specifically, we hypothesized that […]
Read MoreAUTHORS: Xuan, Chengluan MD, PhD et al Anesthesia & Analgesia: June 21, 2021 BACKGROUND: Peripheral nerve block (PNB) with perineural local anesthetic is used for anesthesia or analgesia with many benefits. To extend these benefits, various adjuvant drugs have been used to prolong the duration of analgesia. We aimed to evaluate the effectiveness of various adjuvants […]
Read MoreAUTHORS: Lee, Allison MD, MS et al Anesthesia & Analgesia: June 21, 2021 BACKGROUND: Cervical cerclage is a short ambulatory procedure. For spinal anesthesia, local anesthetic agents with rapid postoperative resolution are desired. We hypothesized that in combination with fentanyl, intrathecal 2-chloroprocaine would produce earlier resolution of motor block, resulting in shorter time to meet recovery […]
Read MoreAUTHORS: Verwijmeren, Lisa MD, PhD et al Anesthesia & Analgesia: June 21, 2021 BACKGROUND: Acute kidney injury (AKI) is associated with mortality after cardiac surgery. Novel risk factors may improve identification of patients at risk for renal injury. The authors evaluated the association between preoperative biomarkers that reflect cardiac, inflammatory, renal, and metabolic disorders and cardiac […]
Read MoreAUTHORS: Stundner, Ottokar MD, MBA et al Anesthesia & Analgesia: June 21, 2021 BACKGROUND: An increasing body of evidence demonstrates an association between obstructive sleep apnea (OSA) and adverse perioperative outcomes. However, large-scale data on open colectomies are lacking. Moreover, the interaction of obesity with OSA is unknown. This study examines the impact of OSA, obesity, […]
Read MoreAUTHORS: Su, Lin MD, PhD et al Anesthesia & Analgesia: June 23, 2021 BACKGROUND: Remifentanil can induce postinfusion cold hyperalgesia. N-methyl-d-aspartate receptor (NMDAR) activation and upregulation of transient receptor potential melastatin 8 (TRPM8) membrane trafficking in dorsal root ganglion (DRG) are critical to cold hyperalgesia derived from neuropathic pain, and TRPM8 activation causes NMDAR-dependent cold response. Contribution […]
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