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Authors: Hao Li, M.D. et al Anesthesiology December 2020, Vol. 133, 1244–1259. Background Acid-sensing ion channel 3 (ASIC3) upregulation has been reported in dorsal root ganglion neurons after incision and contributes to postoperative nociception. This study hypothesized that upregulation of ASIC3 in incised tissues is induced by nerve growth factor through the phosphoinositide 3–kinase/protein kinase […]
Read MoreAuthor: Avery Hurt Practical Pain Management As more states have legalized marijuana for medical and/or recreational purposes – especially after the state measure ballots, cannabis use has become more common across the United States with the CDC reporting that 22.2 million Americans use the substance each month.1 Despite a plethora of sociological and health-based studies […]
Read MoreAuthors: Jasper Kamp, Pharm.D. et al Anesthesiology December 2020, Vol. 133, 1192–1213. Background Several models describing the pharmacokinetics of ketamine are published with differences in model structure and complexity. A systematic review of the literature was performed, as well as a meta-analysis of pharmacokinetic data and construction of a pharmacokinetic model from raw data sets to […]
Read MoreCleveland Clinic If your little one needs surgery, odds are good you have many questions — and concerns. Is it really OK to put kids under general anesthesia? “Anesthesia is very safe. Parents and families shouldn’t be scared,” says pediatric anesthesiologist Julie Niezgoda, MD. Still, it helps to understand what’s involved so you can minimize the […]
Read MoreAuthor: Christina Frangou General Surgery News In patients who underwent abdominal surgery, IV acetaminophen did not reduce the duration of postoperative hypoxemia compared with placebo in a randomized, double-blind trial. In the trial, IV acetaminophen did not significantly reduce postoperative pain, and it reduced opioid consumption by 14%, or 4 mg per day, an amount […]
Read MoreHealthDay News Opioid overdose deaths involving more than one substance are more common among American teens and young adults than deaths caused by opioids alone, researchers report. They also found that stimulants such as cocaine and crystal methamphetamine are the non-opioid substances most commonly involved in opioid overdose deaths in young people. Moreover, opioid overdose […]
Read MoreAuthor: Michael Walter Hospitalized COVID-19 patients who were already taking angiotensin-converting enzyme (ACE) inhibitors have a reduced risk of mortality, according to new findings published in the Journal of the American Heart Association. The authors explored data from more than 700 patients who were treated in one of four regions in Italy from Feb. 22 to […]
Read MoreAuthors Nasir Hussain, M.D., M.Sc. et al Anesthesiology Newly Published on November 2020 Background Spinal morphine is the mainstay of postcesarean analgesia. Quadratus lumborum block has recently been proposed as an adjunct or alternative to spinal morphine. The authors evaluated the analgesic effectiveness of quadratus lumborum block in cesarean delivery with and without spinal morphine. Methods […]
Read MoreAuthors: Maria J. Susano, M.D. et al Anesthesiology December 2020, Vol. 133, 1184–1191. Background Frailty and cognitive impairment are associated with postoperative delirium, but are rarely assessed preoperatively. The study was designed to test the hypothesis that preoperative screening for frailty or cognitive impairment identifies patients at risk for postoperative delirium (primary outcome). Methods In this […]
Read MoreAuthor: Michael Walter Cardiovascular Business News Pre-pregnancy hypertension rates have climbed substantially in the United States in recent years, according to a new analysis published in the Journal of the American College of Cardiology. “Cardiovascular disease (CVD) is now the leading cause of pregnancy-related deaths, and hypertension is a well-established risk factor for these potentially preventable […]
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