Month: November 2020

Uncategorized Published - 26 November, 2020    By - Dr Clemens
HAPPY THANKSGIVING

We want to wish all of our readers a very Happy and healthy Thanksgiving.  Please be safe with your family and friends.

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Uncategorized Published - 25 November, 2020    By - Dr Clemens
Two-Week Multimodal Prehabilitation Program Improves Perioperative Functional Capability in Patients Undergoing Thoracoscopic Lobectomy for Lung Cancer

AUTHORS: Liu, Zijia MD et al Anesthesia & Analgesia: September 2020 – Volume 131 – Issue 3 – p 840-849 BACKGROUND:  Patients with lung cancer often experience reduced functional capacity and quality of life after surgery. The current study investigated the impact of a short-term, home-based, multimodal prehabilitation program on perioperative functional capacity in patients […]

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Uncategorized Published - 25 November, 2020    By - Dr Clemens
Anatomical Evaluation of a Conventional Pectoralis II Versus a Subserratus Plane Block for Breast Surgery

AUTHORS: Robinson, Hal FRCA et al Anesthesia & Analgesia: September 2020 – Volume 131 – Issue 3 – p 928-934 BACKGROUND:  Pectoralis I and II (Pecs I/Pecs II) blocks are modern regional anesthetic techniques performed in combination to anesthetize the nerves involved in breast surgery and axillary node dissection. Pecs II spread and clinical efficacy […]

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Uncategorized Published - 25 November, 2020    By - Dr Clemens
Effects of Obstructive Sleep Apnea and Obesity on Morphine Pharmacokinetics in Children

AUTHORS: Dalesio, Nicholas M. MD, MPH et al Anesthesia & Analgesia: September 2020 – Volume 131 – Issue 3 – p 876-884 BACKGROUND:  Obesity increases susceptibility to chronic pain, increases metabolism, and is associated with obstructive sleep apnea syndrome (OSAS), all which can complicate perioperative pain management of patients. In addition, obesity and OSAS can […]

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Uncategorized Published - 25 November, 2020    By - Dr Clemens
Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm

DG Alerts Despite prevailing assumptions in the literature, cytokine storm syndrome is relatively rare among patients with moderate and severe coronavirus disease 2019 (COVID-19), according to a study published in Science Advances. Rather, the study revealed that the majority of COVID-19 patients exhibited suppressed immune profiles relative to the patterns observed among influenza-infected patients. To understand […]

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Uncategorized Published - 25 November, 2020    By - Dr Clemens
Study shows “major reduction” of NKT cells in patients with severe COVID-19 pneumonia

DG Alerts A study published in Clinical Immunology finds high percentages of NK CD57+ cells and CD56dim NK cells and low percentages of CD56bright and NKT cells among patients with coronavirus disease 2019 (COVID-19) compared to healthy donors. Moreover, the study shows that severe COVID-19 pneumonia and NKT cell reduction were independently associated. “NK cells seem to […]

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Uncategorized Published - 24 November, 2020    By - Dr Clemens
Acute Postoperative Pain Is Associated With Myocardial Injury After Noncardiac Surgery

AUTHORS: Turan, Alparslan MD et al Anesthesia & Analgesia: September 2020 – Volume 131 – Issue 3 – p 822-829 BACKGROUND:  Uncontrolled pain after noncardiac surgery activates the sympathetic nervous system, which causes tachycardia, hypertension, and increased cardiac contractility—all of which may increase myocardial oxygen demand. We therefore determined whether time-weighted average pain scores over […]

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Uncategorized Published - 24 November, 2020    By - Dr Clemens
Physicians Prescribe More Opioid Than Needed to Treat Pain in Children After Outpatient Urological Procedures

AUTHORS: Hunsberger, Joann B. MD, MS et al Anesthesia & Analgesia: September 2020 – Volume 131 – Issue 3 – p 866-875 BACKGROUND:  The epidemic of nonmedical use of prescription opioids (NMUPOs) has been fueled in part by the availability of leftover, legitimately prescribed opioids. In children, outpatient urological procedures are among the most common […]

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Uncategorized Published - 24 November, 2020    By - Dr Clemens
Molecular Interaction Between Butorphanol and κ-Opioid Receptor

AUTHORS: i, Jiafu MD et al Anesthesia & Analgesia: September 2020 – Volume 131 – Issue 3 – p 935-942 BACKGROUND:  The misuse of opioids stems, in part, from inadequate knowledge of molecular interactions between opioids and opioid receptors. It is still unclear why some opioids are far more addictive than others. The κ-opioid receptor […]

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Uncategorized Published - 24 November, 2020    By - Dr Clemens
Thyroid dysfunction in relation to clinical features of patients with COVID-19

DG Alert A study published in the Journal of Clinical Endocrinology & Metabolism shows a 13.1% rate of thyroid dysfunction among patients with predominantly mild-to-moderate coronavirus disease 2019 (COVID-19). “There may be a direct effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on thyroid function, potentially leading to exacerbation of pre-existing autoimmune thyroid disease. Low free […]

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