Month: March 2018

Uncategorized Published - 15 March, 2018    By - Dr Clemens
Standardized Anesthesia Protocol Minimizes Post–Appendectomy Nausea, Vomiting

Implementing a protocol to reduce postoperative nausea and vomiting (PONV) following laparoscopic appendectomy has been found to be effective at facilitating same-day discharges, according to investigators in Ohio. The study tracked a quality improvement (QI) project conducted at Nationwide Children’s Hospital, in Columbus, over a 12-month period. The investigators initially developed and implemented a protocol […]

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Uncategorized Published - 15 March, 2018    By - Dr Clemens
General Anesthesia Imposes Negative Effects on Heart Rate and Blood Pressure Regulation in Patients With a History of Head and Neck Radiation Therapy

AUTHORS: Zheng, Gang MD et al Anesthesia & Analgesia: December 2017 – Volume 125 – Issue 6 – p 2056–2062 BACKGROUND: Head and neck radiation therapy (HNRT) impairs baroreflex sensitivity, and it may potentiate the effects of anesthetics on heart rate (HR) and blood pressure (BP) regulation. Currently, the impacts of HNRT on HR and BP under […]

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Uncategorized Published - 15 March, 2018    By - Dr Clemens
Maternal Death Due to Amniotic Fluid Embolism: A National Study in France

AUTHORS: Bonnet, Marie-Pierre MD, PhD et al Anesthesia & Analgesia: January 2018 – Volume 126 – Issue 1 – p 175–182 BACKGROUND: A structured definition of amniotic fluid embolism (AFE) based on 4 criteria was recently proposed for use in research by the Society for Maternal-Fetal Medicine (SMFM) and the Amniotic Fluid Embolism Foundation. The main objective […]

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Uncategorized Published - 15 March, 2018    By - Dr Clemens
The Understudied Consequences of Peripheral Neuropathy After Chemotherapy

This is for our readers who perform chronic pain management. In 2 articles published in the Journal of the National Cancer Institute researchers have found that peripheral neuropathy can bother patients with early-stage breast cancer years after completing chemotherapy. In addition, a systematic literature review found that only a handful of studies actually tracked long-term peripheral neuropathy, […]

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Uncategorized Published - 15 March, 2018    By - Dr Clemens
Monitoring Patients for Respiratory Compromise: Tactics Should Differ

Monitoring and intervention strategies for patients with respiratory compromise are much more efficient and effective if patients are first categorized by the type of respiratory condition they have. This contrasts with the mentality of monitoring by putting all respiratory patients into the same bucket. This assessment was made following a workshop organized by the National […]

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Uncategorized Published - 14 March, 2018    By - Dr Clemens
Patients Undergoing Cesarean Delivery After Exposure to Oxytocin During Labor Require Higher Postpartum Oxytocin Doses

AUTHORS: Foley, Amanda MD et al Anesthesia & Analgesia: March 2018 – Volume 126 – Issue 3 – p 920–924 BACKGROUND: Experts recommend postpartum oxytocin to prevent uterine atony and hemorrhage, but oxytocin may be associated with dose-dependent adverse effects, and the correct dose of postpartum oxytocin has yet to be determined. The effective dose in 90% […]

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Uncategorized Published - 14 March, 2018    By - Dr Clemens
Intraoperative Esmolol as an Adjunct for Perioperative Opioid and Postoperative Pain Reduction: A Systematic Review, Meta-analysis, and Meta-regression

AUTHORS: Gelineau, Amanda M. MD et al Anesthesia & Analgesia: March 2018 – Volume 126 – Issue 3 – p 1035–1049 BACKGROUND: Esmolol is an ultrashort β-1 receptor antagonist. Recent studies suggest a role for esmolol in pain response modulation. The authors performed a meta-analysis to determine if the intraoperative use of esmolol reduces opioid consumption or […]

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Uncategorized Published - 14 March, 2018    By - Dr Clemens
The Effect of Adductor Canal Block on Knee Extensor Muscle Strength 6 Weeks After Total Knee Arthroplasty: A Randomized, Controlled Trial

AUTHORS: Rousseau-Saine, Nicolas MD et al Anesthesia & Analgesia: March 2018 – Volume 126 – Issue 3 – p 1019–1027 BACKGROUND: Total knee arthroplasty (TKA) reduces knee extensor muscle strength (KES) in the operated limb for several months after the surgery. Immediately after TKA, compared to either inguinal femoral nerve block or placebo, adductor canal block (ACB) […]

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Uncategorized Published - 14 March, 2018    By - Dr Clemens
Targeted Temperature Management After Cardiac Arrest: Systematic Review and Meta-analyses

AUTHORS: Kalra, Rajat MBChB et al Anesthesia & Analgesia: March 2018 – Volume 126 – Issue 3 – p 867–875 BACKGROUND: Targeted temperature management (TTM) with therapeutic hypothermia is an integral component of postarrest care for survivors. However, recent randomized controlled trials (RCTs) have failed to demonstrate the benefit of TTM on clinical outcomes. We sought to […]

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Uncategorized Published - 14 March, 2018    By - Dr Clemens
Novel Opioid Has Faster Onset of Pain Relief, Leads to Fewer Adverse Events

Now in Phase III Trials: An investigational agent designed to improve conventional opioid pharmacology has demonstrated efficacy and safety, as well as faster onset of action, in a pair of pivotal trials. Compared with placebo, patients receiving IV oliceridine (Olinvo, Trevena), a G protein-biased ligand (GPBL) at the mu-opioid receptor, experienced superior relief following bunionectomy or abdominoplasty. Oliceridine also showed favorable […]

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