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Authors: Laurent G. Glance, M.D. et al Anesthesiology 12 2016, Vol.125, 1092-1102. Background: The validity of basing healthcare reimbursement policy on pay-for-performance is grounded in the accuracy of performance measurement. Methods: Monte Carlo simulation was used to examine the accuracy of performance profiling as a function of statistical methodology, case volume, and the extent to which hospital or […]
Read MoreAuthor: Jeffrey W. Sall, Ph.D., M.D. Commentary: Long-term Fate Mapping to Assess the Impact of Postnatal Isoflurane Exposure on Hippocampal Progenitor Cell Productivity Anesthesiology 12 2016, Vol.125, 1090-1091. THE possibility of neurocognitive dysfunction after early exposure to anesthesia is an area of concern for anesthesiologists. Two recent clinical trials (“General Anaesthesia and Awake-Regional Anaesthesia in Infancy” [GAS] […]
Read MoreAuthors: Stefan Muenster, M.D. et al Published in Anesthesiology 11 2016, Vol.125, 952-963 Background: Transfusion of packed erythrocytes stored for a long duration is associated with increased pulmonary arterial pressure and vascular resistance. Prolonged storage decreases erythrocyte deformability, and older erythrocytes are rapidly removed from the circulation after transfusion. The authors studied whether treating stored packed ovine […]
Read MoreAnesthesia & Analgesia: August 31, 2016 AUTHORS: Suresh, Santhanam MD et al BACKGROUND: We evaluated blood bupivacaine concentrations in children having a single-shot sciatic and continuous femoral blocks after anterior cruciate ligament repair. METHODS: Dried blood spot samples were analyzed for bupivacaine levels at 0, 5, 15, 30, 60, and 120 minutes and 4, 24, […]
Read MorePatients with implanted devices for spinal cord stimulation (SCS) for whom paresthesia-based stimulation has failed to relieve pain may have an “effective alternative” in subperception stimulation at 1 kHz, a recent pilot study suggests. The investigators conducted a prospective, randomized study (Neuromodulation2016 May 17. [Epub ahead of print]) to apply the findings of a study […]
Read MoreFor the antifibrinolytic agent tranexamic acid, doses varying between 5 and 15 mg/kg failed to produce a dose-dependent drop in hemoglobin after total knee (TKA) or total hip arthroplasty (THA), leading study investigators to recommend using the lowest of these doses in orthopedic patients. “At my institution, we reviewed quite a bit of data while […]
Read MoreAnil Patel, MD, FRCA Consultant Anaesthetist Royal National Throat, Nose and Ear Hospital University College London Hospitals NHS Foundation Trust London, United Kingdom S.A. Reza Nouraei, MBBChir, PhD, FRCS Ear, Nose, and Throat Surgeon Honorary Senior Lecturer in Otolaryngology, University College London London, United Kingdom High-flow nasal oxygen optimizes preoxygenation and apnea time compared with […]
Read MoreThe US Food and Drug Administration (FDA) review has found that the growing combined use of opioid medicines with benzodiazepines or other drugs that depress the central nervous system (CNS) has resulted in serious side effects, including slowed or difficult breathing and deaths. In an effort to decrease the use of opioids and benzodiazepines, or […]
Read MoreNew research provides insight into a long-observed, but little-understood connection between chronic pain and anxiety and offers a potential target for treatment. The findings, published in Biological Psychiatry, showed that increased expression of a peptide neurotransmitter the body releases in response to stress — pituitary adenylate cyclase activating polypeptide (PACAP) — is also increased in […]
Read MoreAnesthesia & Analgesia: August 29, 2016 AUTHORS: Nasr, Viviane G. MD et al BACKGROUND: Although there have been numerous attempts to predict perioperative mortality in adults, an objective model to predict mortality in children has not been developed. In this study, we aimed to develop a Pediatric Risk Assessment (PRAm) score to predict perioperative mortality […]
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