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Maternal use of pregabalin (Lyrica) might be associated with increased risk for birth defects in offspring, according to a small case-control study in Neurology. In the U.S., pregabalin is approved to treat numerous conditions, including neuropathic pain, seizures, and fibromyalgia. Researchers studied roughly 160 European women exposed to pregabalin during pregnancy and 660 unexposed controls. Excluding […]
Read MoreWomen with migraine face increased risk for cardiovascular events and CV mortality, according to a large prospective study in The BMJ. In the Nurses’ Health Study II, over 115,000 women aged 25 to 42 without angina or CV disease reported whether they’d ever been diagnosed with migraine and then were followed for roughly 20 years. Some […]
Read MoreAuthors: Bradley A. Fritz, M.D. et al Anesthesiology 6 2016, Vol.124, 1265-1276. Background: Anesthesiologists need tools to accurately track postoperative outcomes. The accuracy of patient report in identifying a wide variety of postoperative complications after diverse surgical procedures has not previously been investigated. Methods: In this cohort study, 1,578 adult surgical patients completed a survey at least […]
Read MorePatients using the sumatriptan iontophoretic transdermal patch (Zecuity) to treat migraines could be burned or permanently scarred, warns the FDA. The agency says it has received a “large number” of reports of skin reactions associated with the patch since it went on the market in September 2015. The patch — battery-powered and wrapped around the […]
Read MoreAuthors: J. Lance Lichtor, M.D. et al Anesthesiology 6 2016, Vol.124, 1404-1407. Due to the potentially unforgiving nature of epiglottitis and supraglottitis, the clinician should have a firm understanding of the presentation, work up, and management of a patient presenting with worrisome symptoms. George Washington, the United States’ first president, 2 yr after leaving office on […]
Read MoreAuthors: Christopher Uhlig, M.D. et al Anesthesiology 6 2016, Vol.124, 1230-1245. Background: It is not known whether modern volatile anesthetics are associated with less mortality and postoperative pulmonary or other complications in patients undergoing general anesthesia for surgery. Methods: A systematic literature review was conducted for randomized controlled trials fulfilling following criteria: (1) population: adult patients undergoing general […]
Read MoreThe FDA has approved a buprenorphine implant as a maintenance treatment for opioid dependence. Probuphine, made up of four inch-long rods placed subdermally on the inside of the upper arm, is designed to deliver a steady dose of buprenorphine over a 6-month period. The implant is approved for patients who are already on low-to-moderate doses […]
Read MoreOpioids commonly are used for pain management in patients with osteoarthritis. However, a new study has found that reducing opioid use by half prior to surgery may lead to better functional outcomes. By Thomas G. Ciccone and Forest Tennant, MD, DrPH Interview with Kevin J. Bozic, MD, MBA Managing pain from knee or hip osteoarthritis (OA) is oftentimes […]
Read MoreNumerous peer-reviewed studies have attempted to validate a correlation between patient pain and meteorological conditions, but documenting any sort of repeatable linkage remains a scientific enigma. By Mark A. Young, MD, MBA, FACP and Brandon Bukovitz, BS Patients suffering from chronic pain frequently attribute their symptoms to changes in the weather. In fact, a study revealed that a […]
Read MoreAuthors: Beatrice Beck-Schimmer, M.D. et al Anesthesiology published on 5 2016. Abstract Background: One-lung ventilation during thoracic surgery is associated with hypoxia–reoxygenation injury in the deflated and subsequently reventilated lung. Numerous studies have reported volatile anesthesia–induced attenuation of inflammatory responses in such scenarios. If the effect also extends to clinical outcome is yet undetermined. We hypothesized that […]
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