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Anesthesia & Analgesia: April 2016 – Volume 122 – Issue 4 – p 1070–1078 AUTHORS: Applegate, Richard L. II MD et al BACKGROUND: Diagnostic and interventional procedures are often facilitated by moderate procedure-related sedation. Many studies support the overall safety of this sedation; however, adverse cardiovascular and respiratory events are reported in up to 70% […]
Read MoreAnesthesia & Analgesia: April 2016 – Volume 122 – Issue 4 – p 1062–1069 AUTHORS: Boyer, Richard B. PhD et al BACKGROUND: Rapid infusers are vital tools during massive hemorrhage and resuscitation. Sporadic reports of overheating and shutdown of the Belmont® Rapid Infuser, a commonly used system, have been attributed to 1-sided clot blockage of […]
Read MoreAnesthesia & Analgesia: April 2016 – Volume 122 – Issue 4 – p 1024–1030 AUTHORS: Yuan, Jing MD et al BACKGROUND: It has been increasingly suggested that propofol protects against hypoxic-/ischemic-induced neuronal injury. As evidenced by hemorrhage-induced stroke, hemorrhage into the brain may also cause brain damage. Whether propofol protects against hemorrhage-induced brain damage remains […]
Read MoreAnesthesia & Analgesia: April 2016 – Volume 122 – Issue 4 – p 996–1006 AUTHORS: Richard H. MD, CPHIMS et al BACKGROUND: Reducing fresh gas flow (FGF) during general anesthesia reduces costs by decreasing the consumption of volatile anesthetics and attenuates their contribution to greenhouse gas pollution of the environment. The sevoflurane FGF recommendations in […]
Read MoreAnesthesia & Analgesia: April 2016 – Volume 122 – Issue 4 – p 986–995 AUTHORS: Barrachina, Borja MD et al BACKGROUND: Tranexamic acid (TXA) reduces bleeding in patients undergoing hip replacement surgery, but optimal doses and timing have yet to be established. Our primary objective in this study was to assess total blood loss 48 […]
Read MoreAnesthesia & Analgesia: April 2016 – Volume 122 – Issue 4 – p 976–985 AUTHORS: Grant, Michael C. MD et al BACKGROUND: Preoperative gabapentin has been shown to improve postoperative pain and limit reliance on opioid analgesia. On the basis of an alternative mechanism, our group investigated the ability of preoperative gabapentin to prevent postoperative […]
Read MoreAnesthesia & Analgesia: April 2016 – Volume 122 – Issue 4 – p 969–975 AUTHORS: Rascón-Martínez, Dulce M. MD et al BACKGROUND: Acute postoperative cognitive dysfunction is characterized by neurocognitive dysfunction and confusion. In this study, we compared the cognitive status of a geriatric population undergoing ophthalmic surgery, as assessed by the Short Portable Mental […]
Read MoreAnesthesia & Analgesia: April 2016 – Volume 122 – Issue 4 – p 953–958 AUTHORS: Whitener, George MD et al BACKGROUND: Current guidelines define severe aortic valve stenosis (AS) as an aortic valve area (AVA) ≤1.0 cm2 by the continuity equation and mean gradient (ΔPm) ≥ 40 mm Hg. However, these measurements can be discordant when […]
Read MoreAnesthesia & Analgesia: April 2016 – Volume 122 – Issue 4 – p 943–952 AUTHORS: Claudia Regina MD, PhD et al BACKGROUND: It is unclear whether maintaining pulmonary perfusion and ventilation during cardiopulmonary bypass (CPB) reduces pulmonary inflammatory tissue injury compared with standard CPB where the lungs are not ventilated and are minimally perfused. In […]
Read MoreAnesthesia & Analgesia: April 2016 – Volume 122 – Issue 4 – p 935–942 AUTHORS: Franklin, Sarah W. BA et al BACKGROUND: Bleeding is a serious complication after pediatric cardiopulmonary bypass (CPB) that is associated with an increase in perioperative morbidity and mortality. Four-factor prothrombin complex concentrates (4F-PCCs) have been used off-label to supplement transfusion […]
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