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Edited by André Sofair, MD, MPH, and William E. Chavey, MD, MS Diclofenac, etoricoxib, and rofecoxib were associated with the greatest pain reduction for patients with knee or hip osteoarthritis, while acetaminophen was not superior to placebo, in a network meta-analysis in the Lancet. (Etoricoxib is not available in the U.S.; rofecoxib was withdrawn worldwide in 2004.) Researchers assessed […]
Read Moreby Erica L. Holland, MD; Carli D. Hoaglan, MD; Martha A. Carlstead, CRNA; Ryan P. Beecher, CRNA; Grete H. Porteous, MD Introduction Loss of electrical power in a hospital is a patient safety hazard that has been neglected in medical training and research.1,2 The technology-rich environment of the operating room (OR) puts patients at risk should […]
Read Moreby Karl E. Hammermeister, MD; Michael Bronsert, PhD; Joshua S. Richman, MD, PhD; and William G. Henderson, PhD Historical The earliest description of curare, a naturally occurring predecessor of the neuromuscular blocking agents commonly used today in anesthesia, has been attributed to Sir Walter Raleigh in his 1596 book, The Discoverie of the Large, Rich, and […]
Read Moreby Glenn Murphy, MD The Neuromuscular Research Group at Organon Newhouse Scotland (east of Glasgow) had been working on the development of fast-onset, short-acting, nondepolarizing steroidal neuromuscular blocking agents since the 1960s, which led to the development of pancuronium, vecuronium and rocuronium. Shortly after the launch of rocuronium, questions arose about a possible action of […]
Read MoreWhat Would You Expect If You Were the Patient? by Robert K. Stoelting, MD The Anesthesia Patient Safety Foundation (APSF) believes that residual neuromuscular blockade in the postoperative period is a patient safety hazard that could be addressed partially by better and consistent use of our qualitative standard train-of-four (TOF) nerve stimulator monitors, but will […]
Read MoreMORBID OBESITY AND SLEEP APNEA February 2016 – Volume 29 – Issue 1 – p 134–140 AUTHORS: Lam, Karen K. et al Purpose of review: Perioperative opioid-based pain management of patients suffering from obstructive sleep apnea (OSA) may present challenges because of concerns over severe ventilatory compromise. The interaction between intermittent hypoxia, sleep fragmentation, pain, […]
Read MoreAnesthesia & Analgesia: February 2016 – Volume 122 – Issue 2 – p 490–496 AUTHORS: Hörner, Elisabeth MD et al BACKGROUND: The immediate initiation and high quality of basic life support (BLS) are pivotal to improving patient outcome after cardiac arrest. Although cardiorespiratory monitoring could shorten the time to recognize the onset of cardiac arrest, […]
Read MoreFoulds LT et al., Anaesthesia 2016 Feb 5; In this randomized operating-room study, the McGrath Series 5 video laryngoscope led to better glottic views and fewer intubation failures compared with direct laryngoscopy. Previous studies have shown McGrath video laryngoscopy to be superior to direct laryngoscopy when patients are intubated with manual in-line cervical stabilization and an opened […]
Read MoreLee TH., JAMA 2016 Mar 15; Twelve recommendations focus on opioid use for chronic pain not related to cancer or end-of-life care. Background About 20,000 people died from opioid overdoses in 2014; 3% to 4% of the U.S. population receive prescriptions for long-term opioid therapy. The CDC has released what is considered to be the first federal […]
Read MoreAuthors: Ashley C. Brown, PhD et al Anesthesiology published on 2 2016 Background: Quantitative and qualitative differences in the hemostatic systems exist between neonates and adults, including the presence of “fetal” fibrinogen, a qualitatively dysfunctional form of fibrinogen that exists until 1 yr of age. The consequences of “fetal” fibrinogen on clot structure in neonates, particularly in […]
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