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Patients taking morphine or oxycodone for pain can be safely switched to buprenorphine buccal film without the need for tapering and without causing significant withdrawal or undertreatment of their pain, a new randomized trial suggests. Buprenorphine HCl buccal film is a new transmucosal form of buprenorphine delivered using a small patch placed on the mucosa […]
Read MoreA US Food and Drug Administration (FDA) advisory committee has recommended approval of a new extended-release, abuse-deterrent oxycodone that may be an advance over similar products. The members of the Anesthetic and Analgesic Drug Products Advisory Committee and the Drug Safety and Risk Management Advisory Committee voted 23 to 0 to support approval of Collegium […]
Read MoreBMC Anesthesiol. 2015;15(94) Authors: Huanwei Jiang; Benchao Shi; Shiyuan Xu Background: We herein provide an analysis of lumbar epidural catheterization, which outlines a detailed anatomical description of the epidural anatomy, and may improve the success rate of neuraxial cannulation. Methods: Lumbar epidural catheters were placed in 50 adult embalmed cadavers. After catheterization, the lumbar dura and connecting structures […]
Read MoreIn some large, academic hospitals, busy surgeons often request the concurrent use of multiple operating rooms (ORs), with the goal of increasing efficiency. In the past, the practice has been associated with increased patient time in the OR, but little if any research to date has studied the issue formally. Timothy Harwood, MD, director of […]
Read MoreAnesth Analg. 2015 Sep 1. Authors: Grant MC etc al BACKGROUND: Research has shown that high-risk surgical patients benefit from a multimodal therapeutic approach to prevent postoperative nausea and vomiting (PONV). Our group sought to investigate the effect of administering IV midazolam on PONV. METHODS: This meta-analysis included 12 randomized controlled trials (n = 841) of adults […]
Read MoreAn investigational opioid with a novel mechanism of action produced rapid pain relief in a new study. Results of a double-blind, phase 2 study of the drug (TRV130, Trevena Inc) showed that it was superior to placebo in terms of reducing pain intensity in patients undergoing a bunionectomy, relieving pain within 5 minutes of administration […]
Read MoreClin J Am Soc Nephrol, 2015 Sep 4. Authors: Leite TT et al BACKGROUND AND OBJECTIVES: Propofol has been shown to provide protection against renal ischemia/reperfusion injury experimentally, but clinical evidence is limited to patients undergoing cardiac surgery. There are no data about its association with oliguria and AKI in critically ill patients. DESIGN, SETTING, PARTICIPANTS, & […]
Read MorePain Med 2015 Aug 25 Authors: Morton TL et al OBJECTIVE: To correlate abuse-related pharmacodynamic measures and pharmacokinetic measures after administering immediate-release/extended-release and immediate-release oxycodone/acetaminophen fixed-dose combination analgesics DESIGN: Randomized, double-blind, active- and placebo-controlled, 7-way crossover study SETTING: Contract research organization SUBJECTS: Nondependent recreational users of prescription opioids. METHODS: Participants received single doses of intact immediate-release/extended-release and […]
Read MoreIr J Med Sci 2015 Sep 2. Authors: Baykal Tutal Z et al BACKGROUND AND AIMS: In this study, we compared duration for reaching desired Ramsay Sedation Score (RSS) and postoperative recovery according to Modified Aldrete Score (MAS) of propofol and propofol-ketamine combination in a group of colonoscopy patients. Rates of cardiovascular, respiratory, laryngospasm, visual and nausea/vomiting […]
Read MoreJ Pain Symptom Manage 2015 Nov;50(5):579-86 Authors: Mercadente S et al Fentanyl products have shown superiority to oral opioids for the management of breakthrough cancer pain (BTcP). However, these studies did not use appropriate patient selection, and drugs have been compared by using different rationales. OBJECTIVES: The aim of this randomized, crossover, controlled study was to compare […]
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