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Anesthesia & Analgesia: Sept 2015 Authors: Baeriswyl, Moira MD, et al BACKGROUND: Previous meta-analyses of the transversus abdominis plane (TAP) block have examined a maximum of 12 articles, including fewer than 650 participants, and have not examined the effect of ultrasound-guided techniques specifically. Recently, many trials that use ultrasound approaches to TAP block have been […]
Read MoreCan J Anaesth, 2015 Dec;62(12):1268-1278. Authors: Xiong C et al PURPOSE: Palonosetron, a second-generation 5-hydroxytryptamine 3 receptor antagonist (5-HT3RA), has unique characteristics relative to first-generation 5-HT3RAs such as ondansetron. Nevertheless, it remains unclear if palonosetron is better than ondansetron for the prevention of nausea and vomiting during the first 24 hr after surgery and is thus the […]
Read MoreCan J Anaesth, 2015 Nov;62(11):1169-1178. Authors: Allen M et al PURPOSE: This study aimed to determine if the incidence of recall was equivalent between light and deep sedation for colonoscopy. Secondary analysis included complications, patient clinical recovery, and post-procedure cognitive impairment. METHODS: Two hundred patients undergoing elective outpatient colonoscopy were randomized to light (bispectral index [BIS] 70-80) […]
Read MoreCan J Anaesth, 2015 Dec;62(12):1303-1307 Authors: Thanapaalasgham K et al PURPOSE: Pheochromocytomas (PHEOS) are rare catecholamine-secreting adrenal tumours requiring surgical resection. Preoperative alpha-adrenergic receptor blockade to prevent intraoperative hypertension has traditionally been achieved with phenoxybenzamine. Due to changes in the availability of phenoxybenzamine in Canada, alternate therapies are needed for patients. We report our first experience using […]
Read MoreCapsaicin 8% patch is well-tolerated and provides significant improvements in pain and sleep quality compared with placebo for patients with painful diabetic peripheral neuropathy (PDPN), according to a study presented here at the 51st Annual Meeting of the European Association for the Study of Diabetes (EASD). Capsaicin 8% patch has been used as an analgesic […]
Read MoreThe FDA has granted accelerated approval for idarucizumab (Praxbind) to reverse the anticoagulant effects of dabigatran (Pradaxa) in emergency situations. Idarucizumab, an injectable monoclonal antibody fragment, binds to dabigatran and thereby neutralizes its effect. Approval was based on three trials in which some 280 healthy adults who did not require anticoagulant therapy were given dabigatran […]
Read MoreAuthors: Andrews PJD et al., N Engl J Med 2015 Oct 7; A multicenter randomized trial was stopped early because hypothermia worsened outcomes when used as second-line therapy for elevated intracranial pressure. Induced hypothermia has become popular for treating cerebral edema from traumatic brain injury (TBI), but we do not know the effect on long-term […]
Read MoreDear Q&A, We write to describe an instance of anesthesia machine ventilator failure during provision of anesthesia. The case in point was an emergency vascular operation for a pulseless lower extremity. In preparation for the case, the anesthesia machine checkout was performed on the Dräger GS Premium. All tests confirmed that the anesthesia machine was […]
Read MoreDear Q&A, We were using oxygen and air with sevoflurane for a case in the cystoscopy suite. During the maintenance phase of the case, we found what we assumed to be water inside the air flowmeter, with its float rising and dropping rapidly and the liquid spilling into the next flowmeter (nitrous oxide). We promptly […]
Read MoreBy Lorri A. Lee, MD, and Tricia A. Meyer, PharmD, MS, FASHP An estimated one million people in the United States have been diagnosed with Parkinson’s Disease (PD) making it one of the most common neurological disorders in patients. This number is estimated to double in the next 30 years as PD is associated with […]
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