Uncategorized Published - 30 November, 2015 By - Dr Clemens

Nitrous Oxide and Serious Long-term Morbidity and Mortality in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II Trial

Authors: Kate Leslie, MBBS, MD, M.Epid, M.Hlth Serv, Mt FANZCA, et al Anesthesiology 12 2015, Vol.123, 1267-1280. Background: The Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II trial randomly assigned 7,112 noncardiac surgery patients at risk of perioperative cardiovascular events to 70% N2O or 70% N2 groups. The aim of this follow-up study was to determine […]

Uncategorized Published - 30 November, 2015 By - Dr Clemens

An Expedited Care Pathway with Ambulatory Brachial Plexus Analgesia Is a Cost-effective Alternative to Standard Inpatient Care after Complex Arthroscopic Elbow Surgery: A Randomized, Single-blinded Study

Authors: Hillenn Cruz Eng, MD, et al Anesthesiology 12 2015, Vol.123, 1256-1266. Background: Common standard practice after complex arthroscopic elbow surgery includes hospital admission for 72 h. The authors hypothesized that an expedited care pathway, with 24 h of hospital admission and ambulatory brachial plexus analgesia and continuous passive motion at home, results in equivalent elbow range of […]

Uncategorized Published - 30 November, 2015 By - Dr Clemens

Inflammation Increases Neuronal Sensitivity to General Anesthetics

Authors: Sinziana Avramescu, MD, PhD, et al Anesthesiology published on 11 2015. Background: Critically ill patients with severe inflammation often exhibit heightened sensitivity to general anesthetics; however, the underlying mechanisms remain poorly understood. Inflammation increases the number of γ-aminobutyric acid type A (GABAA) receptors expressed on the surface of neurons, which supports the hypothesis that inflammation increases up-regulation […]

Uncategorized Published - 30 November, 2015 By - Dr Clemens

Morbidity and Mortality after High-dose Transfusion

Authors: Daniel J. Johnson, B.S. el at Anesthesiology published on 11 2015. Background: It is well recognized that increased transfusion volumes are associated with increased morbidity and mortality, but dose–response relations between high- and very-high-dose transfusion and clinical outcomes have not been described previously. In this study, the authors assessed (1) the dose–response relation over a wide […]

Uncategorized Published - 30 November, 2015 By - Dr Clemens

Impact of Perioperative Epidural Placement on Postdischarge Opioid Use in Patients Undergoing Abdominal Surgery

Authors: Karim S. Ladha, MD M.Sc et al Anesthesiology published on 11 2015. Background: Opioids play a crucial role in providing analgesia throughout the perioperative period; however, patients may become persistent users of these medications months after surgery. Epidurals have been posited to prevent the development of persistent pain, but there are little data on the effect […]