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The US Food and Drug Administration (FDA) has granted accelerated approval to Praxbind (idarucizumab, Boehringer Ingelheim) to rapidly reverse the blood-thinning effects of the anticoagulant Pradaxa (dabigatran, Boehringer Ingelheim). “The anticoagulant effects of Pradaxa are important and life-saving for some patients, but there are situations where reversal of the drug’s effects is medically necessary,” said […]
Read MoreA perspective in the New England Journal of Medicine discusses the FDA’s risk assessment of serious neurologic events associated with the off-label use of epidural glucocorticoid injections. In April 2014, the FDA required a label change for injectable corticosteroids — which are commonly used to treat neck and back pain — to warn about “rare but serious,” […]
Read MoreAuthors: Hassan Farhan, M.D. et al Anesthesiology 10 2015. Abstract Muscle weakness is common in the surgical intensive care unit (ICU). Low muscle mass at ICU admission is a significant predictor of adverse outcomes. The consequences of ICU-acquired muscle weakness depend on the underlying mechanism. Temporary drug-induced weakness when properly managed may not affect outcome. Severe […]
Read MorePatients undergoing bariatric surgery show a small but definite increase in self-harm emergencies after the procedure, researchers report in JAMA Surgery. Using Ontario provincial health records, the researchers compared rates of self-harm incidents in the 3 years preceding surgery versus the 3 years following it in some 8800 patients. Self-harm was measured as emergency visits for […]
Read MoreRegional Anesthesia & Pain Medicine: July/August 2015 – Volume 40 – Issue 4 – p 315–320 Authors: Tiyaprasertkul, Worakamol MD Background and Objectives: This prospective randomized trial compared ultrasound-guided single-injection (SI) and triple-injection (TI) subparaneural popliteal sciatic nerve block. We hypothesized that multiple injections are not required when local anesthetic (LA) is deposited under the […]
Read MoreAuthors: Ajay D. Wasan, M.D., M.Sc. et al Anesthesiology 10 2015, Vol.123, 861-872. Background: Opioids are frequently prescribed for chronic low back pain (CLBP), but there are little prospective data on which patient subgroups may benefit. Psychiatric comorbidity, such as high levels of depression and anxiety symptoms (termed comorbid negative affect [NA]), is a common presentation and […]
Read MoreAuthors: Karthik Raghunathan, M.D., M.P.H. et al Anesthesiology 9 2015 Background: Currently, guidelines recommend initial resuscitation with intravenous (IV) crystalloids during severe sepsis/septic shock. Albumin is suggested as an alternative. However, fluid mixtures are often used in practice, and it is unclear whether the specific mixture of IV fluids used impacts outcomes. The objective of this study […]
Read MoreAuthors: Drake-Brockman TF et al., Anaesthesia 2015 Sep 10; In anesthetized spontaneously breathing children, leakage volume was greater, device dislodgement was more common, and first-attempt insertion success was lower with the i-gel. The i-gel is an extraglottic device with a noninflatable cuff made of a flexible gelatinous material. The PRO-Breathe is a silicone-based standard laryngeal mask airway […]
Read MoreAuthors: Hillenn Cruz Eng, M.D. et al Anesthesiology 9 2015 Background: Common standard practice after complex arthroscopic elbow surgery includes hospital admission for 72 h. The authors hypothesized that an expedited care pathway, with 24 h of hospital admission and ambulatory brachial plexus analgesia and continuous passive motion at home, results in equivalent elbow range of motion […]
Read MoreAuthors: Kelly A. Pollak, M.D. Anesthesiology 9 2015 Background: The authors examined changes in the frequency of pain medicine malpractice claims and associated treatment modalities and outcomes over time. Methods: The authors analyzed trends in pain medicine claims from 1980 to 2012 in the Anesthesia Closed Claims Project database by binary logistic regression on year of event. Pain […]
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