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Authors: Marco G et al., Anesth Analg 2015 Jun 3; Increasing body-mass index, age, and propofol dose were predictors of swallowing impairment and aspiration in this single-center observational study. Deep sedation is becoming increasingly popular in a variety of clinical settings to facilitate medical and surgical procedures. Sedatives have the potential to affect swallowing function and protective […]
Read MoreAuthors: Campbell G et al; Pain Med, 2015 May 22 OBJECTIVE: There is increasing concern about the appropriateness of prescribing pharmaceutical opioids for chronic non-cancer pain (CNCP), given the risks of problematic use and dependence. This article examines pharmaceutical opioid dose and dependence and examines the correlates of each. DESIGN: Baseline data were obtained from a […]
Read MoreThe US Food and Drug Administration has approved fentanyl iontophoretic transdermal system (Ionsys, The Medicines Co), the first needle-free, patient-controlled, preprogrammed fentanyl delivery system for management of acute postoperative pain in adults requiring opioid analgesia in the hospital, according to a company news release. Ionsys is a “novel alternative” to traditional intravenous patient-controlled analgesia that uses […]
Read MoreEur J Clin Pharmacol 2015 Jun;71(6):723-32 Authors: Ilomaki J et al PURPOSE: Due to potential drug-drug interactions and subsequent bleeding risk, analgesic use should be reviewed when an oral anticoagulant is initiated. The aim of this study was to compare use of non-steroidal anti-inflammatory drugs (NSAIDs) and other analgesics before and after oral anticoagulant initiation. METHODS: All […]
Read MoreAuthors: Liu FL et al; Can J Anaesth. 2015 May PURPOSE: Obese patients present a challenge to safe general anesthesia because of impaired cardiopulmonary physiology and increased risks of aspiration and acute upper airway obstruction. Since studies are lacking regarding the postoperative effects on recovery from general anesthesia in morbidly obese patients, we conducted a systematic […]
Read MoreTroubled Maquet’s woes continue. On the heels of a permanent injunction from the Department of Justice that resulted in the halt of manufacturing at one of its facilities, the suspension of 5 of its devices from the market and a $6 million fine, the FDA just warned practitioners that the company’s Flow-i Anesthesia Systems have a problem that […]
Read MoreAuthors: Luedtke K et al., BMJ 2015 350:h1640 A study of transcranial stimulation preceding behavioral cognitive therapy does not support the effectiveness of this procedure for the treatment of low back pain. Chronic low back pain is a frequent and costly problem for which few interventions are effective. Chronic low back pain is characterized by a number […]
Read MorePatients with complications after major surgery are 26% more likely to survive if they return to the hospital where they had their operation, researchers find. Patients with complications after major surgery have better survival odds if they’re readmitted to the same hospital where the surgery was performed, throwing into doubt the assumption that travel long […]
Read MoreAuthors: Pollack CV Jr et al., N Engl J Med 2015 Jun 22 Idarucizumab immediately reversed dabigatran-induced increases in clotting variables without causing serious adverse events. Dabigatran is a direct thrombin inhibitor that is approved for the prevention of stroke in atrial fibrillation and for the treatment of venous thromboembolism. Bleeding is usually managed by discontinuing the drug or, […]
Read MoreAuthors: Stéphan F et al., JAMA 2015 Jun 16; 313:2331 In one trial, intubation rates were similar to those of noninvasive positive pressure ventilation, and 90-day mortality was lower. Use of noninvasive positive pressure ventilation (NPPV) in patients with chronic obstructive pulmonary disease exacerbations and cardiogenic pulmonary edema is well established, but its value in treating patients […]
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