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The US Food and Drug Administration (FDA) has approved the extended-release (ER) single-entity opioid analgesic hydrocodone bitartrate (Hysingla ER, Purdue Pharma) with abuse-deterrent properties in line with the FDA’s 2013 draft guidance to industry, the agency announced. “Hysingla ER has properties that are expected to reduce, but not totally prevent, abuse of the drug when […]
Read MoreRandomized Study in Chinese and Caucasian Subjects Authors: Xinmin Wu et al Published in BMC Anesthesiol. 2014;14(53) Background This study compared efficacy and safety of the selective relaxant binding agent sugammadex (2 mg/kg) with neostigmine (50 μg/kg) for neuromuscular blockade (NMB) reversal in Chinese and Caucasian subjects. Methods This was a randomized, active-controlled, multicenter, safety-assessor-blinded study (NCT00825812) in […]
Read MoreArticle of our pain providers. Published in Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc. Author(s): Anghelescu D, Goldberg J, Faughnan L, Wu J, Mao S, Furman W, Santana V, Navid F Treatments discussed: ch14.18, morphine BACKGROUND Addition of anti-GD2 antibody ch14.18 to the treatment of neuroblastoma has improved outcomes. The most common side effect of ch14.18 […]
Read MoreThis is for our pain clinic providers. The best predictor of a speedy recovery after a sports-related concussion is simply the initial symptom burden as measured by the Post-Concussion Symptom Scale (PCSS), a new study suggests. Other measures, including computerized neurocognitive testing, are not predictive, according to the study results. “The bottom line is that […]
Read MoreA study published in the November issue of the journal Pain found an increased risk of death associated with chronic pain without opioid treatment, as well as an even higher risk among those prescribed opioids for long-term use and a somewhat lower risk associated with short-term use. “Our study provides the first evidence that directly […]
Read MoreThis is for our providers treating chronic pain patients. For patients with osteoarthritis, a formulation of the nonsteroidal anti-inflammatory drug (NSAID) diclofenac, developed with SoluMatrix fine-particle technology (Zorvolex, Iroko Pharmaceuticals), improves health-related quality of life, physical function, and pain, according to a phase 3 open-label study. “We re-engineered diclofenac to enable lower doses to be used, […]
Read MorePatients undergoing elective surgery may fare better if they receive regional anesthesia (RA) instead of general anesthesia (GA), according to researchers at Vanderbilt University Medical Center, in Nashville, Tenn. The study found that 0.81% of adults receiving RA died within 30 days of surgery, compared with 1.13% of those receiving GA (abstract JS01). It’s a […]
Read MoreMedical and surgical patient costs reduced as well Patients who declined transfusions but were treated with blood-conservation methods suffered fewer deaths, infections and other morbid outcomes compared with those who accepted donor blood and received standard care, a new Johns Hopkins study concluded. Mortality rates were almost fourfold lower in patients who declined allogeneic blood […]
Read MoreMalignant hyperthermia (MH) can be a life-threatening condition and diagnosing it can be a challenge. A chart review by an international research team led by Columbia University Medical Center, New York City, and sponsored by the Malignant Hyperthermia Association of the United States (MHAUS) has concluded that approximately 70% of International Classification of Diseases (ICD)-9– […]
Read MoreAuthors: Ibrahim I et al., Acad Emerg Med 2015 Mar 2; Drawing ABGs with a 29-gauge insulin needle instead of a standard needle is less painful and has fewer complications but results in slightly more hemolysis. While venous blood gas analysis has replaced arterial blood gas (ABG) analysis for many illnesses treated in the emergency […]
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