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This was written by Elizabeth A. M. Frost, MD Professor of Anesthesia Icahn School of Medicine at Mount Sinai New York, New York Many questions have arisen and much controversy has emerged regarding how much fluid should be given perioperatively, which fluids should be given, when they should be given, and whether outcomes can be […]
Read MoreThis is for our readers who practice pain management. Authors: Wojahn RD et al., J Bone Joint Surg Am 2014 Nov 19; 96:1849 Almost half of patients required no additional injections. The estimated lifetime risk for trigger finger is about 3% in the general population and as high as 10% in diabetic patients. Treatment options […]
Read MoreExcitement is mounting about a new class of drugs for migraine prevention. In one of the most recent developments, a new phase 2 trial of ALD403, a humanized monoclonal antibody directed against calcitonin gene-related peptide (CGRO) showed that the drug was safe and effective. Results also showed that adverse events associated with the drug were […]
Read MorePublished in Rheumatology International (Sep 2014) Authors: Bjersing J et al Fibromyalgia (FM) is characterized by generalized chronic pain and reduced pain thresholds. Disturbed neuroendocrine function and impairment of growth hormone/insulin-like growth factor-1 is common. However, the pathophysiology of FM is not clear. MicroRNAs are important regulatory factors reflecting interface of genes and environment. Our […]
Read MoreMemantine, a drug primarily used to treat patients with Parkinson’s disease and Alzheimer’s disease, reduced pain and improved quality of life in patients with fibromyalgia, according to a study published in Pain. “This is the first randomised, controlled study of memantine for the treatment of fibromyalgia,” write Bárbara Oliván-Blázquez, from the Department of Psychology and […]
Read MorePatients who receive epinephrine during resuscitation after cardiac arrest are less likely to survive with a good neurologic outcome, a study in the Journal of the American College of Cardiology suggests. Researchers analyzed data from more than 1500 patients who were successfully resuscitated after an out-of-hospital cardiac arrest and were subsequently treated at a large […]
Read MoreAuthors: Cohen SP et al., Anesthesiology 2014 Nov 121:1045 In a nonblinded, randomized trial, epidural steroid injections were not significantly better than conservative treatment. Data on epidural steroid injections for cervical radiculopathy are largely observational, and results of the few small randomized trials have been inconclusive. In this multicenter trial, U.S. investigators randomized 169 patients […]
Read MorePublished in Pediatr Blood Cancer. 2015 Jan;62(1):85-90. Authors: Whitlow PG et al BACKGROUND: Lumbar punctures are frequently performed in pediatric leukemia for central nervous system leukemic prophylaxis. The contribution of local anesthetic with deep sedation is unknown. The objective was to evaluate EMLA (eutectic mixture of local anesthetics) cream as a pain reliever in conjunction […]
Read MoreAuthors: Miner JR et al., Ann Emerg Med 2014 Oct 15; In a randomized trial, three drug regimens for procedural sedation were equivalent, but the analysis was flawed. For procedural sedation, the advantage of propofol is its short duration; its disadvantage is dose-related respiratory suppression. The advantage of ketamine is absence of respiratory suppression; its […]
Read MoreThis is for our anesthesia providers who also perform critical care medicine. Authors: Funk D et al., Crit Care Med 2014 Nov 42:2333 In an observational study, steroid therapy was associated with lower mortality in the sickest patients. The most recent Surviving Sepsis Guidelines (Crit Care Med 2013; 41:580) suggest that steroids (200 mg hydrocortisone […]
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