ASA Monitor May 2024, Vol. 88, 27.
Researchers at the National Institutes of Health (NIH) investigated the immune system responses and microbiome changes in individuals who switched between a vegan and ketogenic (keto) diet over two-week periods. They found that the vegan diet stimulated innate immunity, while the keto diet triggered adaptive immune responses. The study involved 20 diverse participants who consumed each diet for two weeks, with blood, urine, and stool samples collected for analysis. The vegan diet was low in fat and high in fiber, while the keto diet was high in fat and low in carbohydrates. While the keto diet more heavily affected levels of more proteins in the blood plasma and a wider range of tissues, such as the blood, brain, and bone marrow, the vegan diet’s higher iron content promoted more red blood cell-linked pathways, including those involved in heme metabolism. Both diets caused significant changes in participants’ metabolic and immune pathways, with the keto diet affecting a broader range of tissues and proteins. Additionally, both diets led to shifts in the gut microbiome composition. Despite participant diversity, consistent metabolic and immune responses were observed, indicating the rapid impact of dietary changes on the body. The study suggests the potential for tailored diets to prevent or complement disease treatments. Further investigation is needed to understand specific immune system components affected by nutritional interventions and to understand the implications of these changes on diseases like cancer and inflammatory conditions.
Source: asamonitor.pub/4a5UR0O
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