We thank Dr. Enlund very much for his comments and motivating words.  The interactions of anesthetics with key mechanisms in energy metabolism and ion homeostasis occur simultaneously as we observed in our experiments.  These complex interactions might be relevant for both neuroprotection and neurotoxicity associated with deep anesthesia. Changes in intracellular adenosine triphosphate (ATP) concentrations regulate the activity of the adenylate kinase in neurons. Because isoflurane decreases Na+/K+-ATPase activity and neuronal metabolism, interactions with the adenylate kinase with subsequent modulation of cAMP-related processes are more than possible. We are going to include these possible interactions in our mind map for our future hypothesis and experimental work. We again thank Dr. Enlund for this valuable and inspiring input.