CONTEXT: Intranasal dexmedetomidine (IND) is an emerging agent for procedural distress in children.
OBJECTIVE: To explore the effectiveness of IND for procedural distress in children.
CONCLUSIONS: Given the methodologic limitations of included trials, IND is likely more effective at sedating children compared to oral chloral hydrate and oral midazolam. However, this must be weighed against the potential for adverse cardiovascular effects.
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