Which of the following immunosuppressive drugs is MOST likely to cause renal dysfunction?

  • □ (A) Tacrolimus
  • □ (B) Mycophenolate mofetil
  • □ (C) Basiliximab

Immunosuppressant drugs are used to prevent or treat allograft rejection. Most of these drugs act during the induction phase of the immunological response, reducing lymphocyte proliferation. Some of them are also used in the maintenance phase. There are three main groups based on the site of action: interleukin-2 (IL-2) production or action, cytokine gene expression, or purine or pyrimidine synthesis. Complications of chronic immune suppression drugs are shown in the Table.