Conclusions: β-Blockers were reintroduced early (after less than 48 h) in fewer than half of the cardiac surgery patients. Reintroduction decreased postoperative atrial fibrillation occurrence only at later time points and only in the predictor selected set model. These results are an incentive to optimize (timing, doses, or titration) β-blocker reintroduction after cardiac surgery.
What We Already Know about This Topic:
β-blockers are usually stopped in cardiac surgical patients
When best to reintroduce them remains unknown, and is a trade-off between hemodynamic risk and development of atrial fibrillation
What This Article Tells Us That Is New:
There was little advantage to reintroducing β-blockers within 48 h
The odds of atrial fibrillation were significantly reduced by restarting β-blockers between 72 and 96 h after surgery