Congress Pressures FDA to Finalize Opioid Guidance

This is some general information for our pain providers. Threatens to shift $20 million from agency if abuse-deterrent guidance isn’t settled by June. The FDA will publish its long-awaited guidance on abuse-deterrent opioids by the end of June, in order to avoid a $20 million cut in funds to the commissioner’s office threatened by Congress. […]

Blood/Gas partition coefficients for isoflurane, sevoflurane, and desflurane in a clinically relevant patient population

Published in Anesth Analg. 2015 Jan;120(1):45-50 Authors: Esper T et al BACKGROUND: The blood/gas partition coefficient of a certain volatile anesthetic is of clinical importance because it determines its velocity of uptake into and elimination from the body of a patient and thus its pharmacokinetic behavior. To date, the blood/gas partition coefficients of isoflurane, sevoflurane, and […]

Bilateral Paravertebral Blockade (T7-10) Versus Incisional Local Anesthetic Administration for Pediatric Laparoscopic Cholecystectomy: A Prospective, Randomized Clinical Study

Published in Anesth Analg. 2014 Nov 25 Authors: Visoiu M et al BACKGROUND: Single-injection paravertebral nerve blocks (PVBs) provide effective postoperative analgesia after adult laparoscopic cholecystectomy (LC). We sought to compare PVBs with local anesthetic injections at laparoscopic port sites in a pediatric population. METHODS: Eighty-three patients (8-17 years old) scheduled for LC were randomized prospectively […]

Are caudal blocks for pain control safe in children? an analysis of 18,650 caudal blocks from the Pediatric Regional Anesthesia Network (PRAN) database

Published in Anesth Analg. 2015 Jan;120(1):151-6 Authors: Suresh S et al BACKGROUND: The caudal block is the most commonly performed regional anesthesia technique in pediatric patients undergoing surgical procedures, but safety concerns raised by previous reports remain to be addressed. Our main objective in current investigation was to estimate the overall and specific incidence of complications […]

Fentanyl: DEA Sounds Nationwide Alarm on Drug’s Dangers

The US Drug Enforcement Agency (DEA) has issued a nationwide alert about the dangers of the narcotic fentanyl and fentanyl analogues/compounds. According to the DEA, the drug, which is often used in anesthesia to prevent pain after surgery or other procedures, is commonly laced in heroin, causing significant problems across the country, particularly because heroin […]

Surgical space conditions during low-pressure laparoscopic cholecystectomy with deep versus moderate neuromuscular blockade: a randomized clinical study

Published in Anesth Analg. 2014 Nov;119(5):1084-92 Authors: Staehr-Rye AK et al BACKGROUND: Laparoscopic cholecystectomy performed during low intraabdominal pressure (<12 mm Hg) is associated with significantly less postoperative pain than standard pressure (≥12 mm Hg). The impact on surgical space conditions and safety of operating at lower pressures has not been adequately described, but deep neuromuscular […]

A dose-response study of caudal dexmedetomidine with ropivacaine in pediatric day care patients undergoing lower abdominal and perineal surgeries: a randomized controlled trial.

Published in Paediatr Anaesth. 2014 Nov;24(11):1158-63 Authors: Bharti N et al OBJECTIVES: This randomized double-blind study was conducted to evaluate the analgesic efficacy and safety of addition of three different doses of dexmedetomidine in caudal ropivacaine compared with plain ropivacaine for postoperative analgesia in pediatric day care patients. METHODS: Eighty children of American Society of Anesthesiologists […]

The importance of pleural integrity for effective and safe thoracic paravertebral block: a retrospective comparative study on postoperative pain control by paravertebral block

Published in CardioVasc Thoracic Surgery Volume 20, Issue 3 Pp. 296-299 Authors: Teruya Komatsua et al OBJECTIVES Recently, paravertebral block (PVB) has been reported to be an effective analgesic modality for post-thoracotomy pain, but there is no consensus on how thoracic PVB can be more effective. Our hypothesis that intact pleura has a significant impact on the analgesic […]

Postoperative Delirium Guideline for Older Adults Issued

The American Geriatrics Society (AGS) has released a new practice guideline for preventing and treating postoperative delirium in patients aged 65 years or older. The guideline was published onlineNovember 4 on the AGS website. An additional best practices document containing almost all guideline recommendations plus additional clinical recommendations was published in the Journal of the American College of Surgeons. The […]