Technology in Anesthesiology

A new method for detecting cancer, combining PANORAMA imaging with fluorescent imaging, demonstrates a 98.7% accuracy rate and potential for detecting cancer in its earliest stages, potentially revolutionizing cancer diagnosis. This method allows researchers to examine nanometer-sized membrane sacs called extracellular vesicles (EVs) in the bloodstream, which carry various cargos. By analyzing small EVs in samples from both healthy individuals and those with cancer, researchers observed significant differences in both small EV numbers and cargo. The PANORAMA optical imaging technology played a crucial role in this research, enabling the visualization, counting, sizing, and cargo analysis of small EVs. The study found that using a cutoff of 70 normalized small EV counts, cancer detection sensitivity reached 99.5%, with a specificity of 97.3%. Further testing with independent sample sets confirmed the accuracy of this detection threshold across different types and stages of cancer. The researchers suggest that with optimization, this approach could become a valuable tool for cancer screening and provide deeper insights into cancer biology and small EVs.

Source: asamonitor.pub/4c72EMP