Long-Term Use of Opioid Patches Common Among Persons With Alzheimer’s Disease

Approximately 7% of people with Alzheimer’s disease use opioids for non-cancer pain for a period longer than 6 months, according to a study published in the journal Pain.

One third of people initiating opioid use became long-term users, and long-term use was heavily associated with transdermal opioid patches.

Researchers from the University of Eastern Finland, Kuopio, Finland, found that long-term use of opioids was approximately as common among persons with Alzheimer’s disease as it was among those without it. However, long-term use of transdermal patches was twice as common among persons with Alzheimer’s disease, while tablet form opioids were more common among those without Alzheimer’s disease.

In addition, long-term opioid use together with benzodiazepines was common, which is worrying as both medicines cause drowsiness.

The use of opioids was studied from the date of Alzheimer’s disease diagnosis until death or admission into a long-term care facility. Those with active cancer treatment were excluded from the analysis.

Long-term opioid use is a problematic practice for non-cancer pain. Evidence of its benefits is limited, and the risk of adverse effects is increased compared with short-term treatment. Further, research on the benefits and adverse effects of long-term opioid use is very scarce among older adults and especially those with dementia. Changing doses and stopping medication when using patch-form opioids requires more time and thus, entails more careful monitoring. Pain, the need for analgesics, and possible adverse effects related to analgesics should be assessed regularly among persons with dementia.

The study is part of the MEDALZ cohort, which included 67,215 persons with Alzheimer’s disease diagnosed from 2005 to 2011, of whom 13,111 initiated opioid use. Each person with the disease was matched with a comparison person without Alzheimer’s disease of the same age, gender and region of residence. Data for the study were derived from Finnish nationwide registers.