Anesthesia Experts

Dapagliflozin OK’ed for Heart Failure with Low EF, Regardless of Type 2 Diabetes Status

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Author: Kristin J. Kelley

The FDA has approved the sodium-glucose co-transporter 2 (SGLT2) inhibitor dapagliflozin (Farxiga) to lower the risk for cardiovascular death and heart failure hospitalization in patients with heart failure with reduced ejection fraction. The indication is for adults, regardless of whether they have type 2 diabetes.

Approval was based on results from a randomized trial in which patients treated with dapagliflozin had lower rates of cardiovascular death, urgent heart failure, or heart failure hospitalization than those on placebo. Common treatment side effects include dehydration, urinary tract infections, and yeast infections.

Dapagliflozin was approved to reduce risk for heart failure hospitalization in patients with type 2 diabetes in 2019. It is currently being studied as a possible treatment for novel coronavirus disease (COVID-19).

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