To the Editor:
Although influenza vaccination is recommended for all children 6 months of age and older, American vaccination rates are well below U.S. Department of Health and Human Services (Washington, D.C.) target goals. To increase vaccination rates, the Centers for Disease Control and Prevention (Atlanta, Georgia) and the American Academy of Pediatrics (Itasca, Illinois) recommend influenza vaccination during all healthcare-seeking opportunities including the perioperative period.
No longer limited to the primary care setting, we hypothesized that the perioperative period would be an ideal setting to increase influenza vaccination in children. In the United States, approximately 6 million children under the age of 18 yr undergo general anesthesia annually. Because general anesthesia is so fraught with fear and anxiety, it is a “teachable moment,”—that is, an event that “motivates individuals to spontaneously adopt risk-reducing health behaviors” and would help overcome resistance to vaccination. Further, to “sweeten the pot,” vaccination under general anesthesia provides several benefits, including patient comfort, expedited care, and leveraging existing workflows and processes that we also believed would increase vaccination rates. Additionally, in the fall of 2020, we were faced with the prospect of a combined influenza epidemic and COVID-19 pandemic.
Thus, we implemented a standardized process to actively offer influenza vaccination to all our patients undergoing elective general anesthesia. We sought to increase the number of vaccines given under general anesthesia and understand patient factors associated with vaccine acceptance. We conducted multivariate multilevel mixed logistic regression analyses, accounting for repeat procedures per patient within a given season, to determine if the intervention was associated with the outcome of perioperative vaccination, while controlling for all patient- and procedure-level data that yielded statistical significance when examined at a bivariate level. All analyses were conducted using Stata 17.0 (StataCorp LP, USA).
Our quality improvement process included forming a multidisciplinary team, modifications to the electronic health record, nurse standing order utilization, data analytics, and development of a best practice workflow (fig. 1). Specifically, during preoperative registration, a best practice advisory in the electronic health record specific to perioperative areas prompted nursing staff to (1) determine and document influenza vaccination status, (2) determine eligibility for vaccination, and (3) order inactivated influenza vaccine using existing hospital standing orders if consent/assent for vaccination was obtained. The vaccine was then sent from pharmacy and placed on the patient’s chart to be given after induction of anesthesia by the anesthesia team or circulating nurse. The vaccine was documented in the electronic health record, populated in the state immunization registry, and included in the after-visit/discharge summary (fig. 1).
After obtaining approval by the Organizational Research Risk and Quality Improvement Review Panel for Children’s Hospital Colorado (Aurora, Colorado), parental consent, and when applicable, patient assent, we offered the influenza vaccine to all patients undergoing elective general anesthesia at our tertiary care, freestanding children’s hospital between October 2020 to March 2021. Additionally, Colorado Multiple Institutions Review Board (Aurora, Colorado; No. 21-2654) approval was obtained to review the data. The number of patients receiving the vaccine in this intervention was compared to the previous year’s nonstandardized process.
There were 6,841 and 6,858 perioperative visits (children younger than 18 yr) in our preintervention and intervention periods, respectively. Our standardized process significantly increased influenza vaccinations by sixfold. Specifically, in the preintervention period, only 140 patients (2%) were vaccinated compared to 930 (13.6%) during the intervention period (odds ratio, 0.1509; 95% CI, 0.1259 to 0.1808; P < 0.001). There were minor and likely unimportant differences in the demographics between the reference and intervention years. In the intervention year, children who were vaccinated under anesthesia were more likely to be older (median, 98.5 vs. 91 months), Hispanic (33% vs. 26.8%), and discharged after the procedure (86.8% vs. 81.2%). Further, in multivariate multilevel mixed logistic regression analyses, factors associated with perioperative vaccination included the intervention season (odds ratio, 15.49; 95% CI, 9.58 to 25.05), Hispanic ethnicity (odds ratio, 1.39; 95% CI, 1.11 to 1.75), and vaccination in October and November (odds ratio, 3.38; 95% CI, 2.30 to 4.96; and odds ratio, 2.40; 95% CI, 1.72 to 3.36, respectively). Of the 127 patients who were vaccinated and scheduled for postoperative admission to the hospital, only one developed a temperature greater than 38.4°C in the first 48 h postoperatively. On the other hand, 6 of 1,251 nonvaccinated patients admitted during the same time period developed a fever. Additionally, there were no reports in our hospital’s safety reporting system of adverse or serious safety events related to vaccination (seizures, anaphylaxis, or injection site pain, swelling, or erythema) in either ambulatory patients or those admitted to the hospital postoperatively. Finally, this was an observational cohort study with all its inherent limitations.
In conclusion, low influenza vaccination rates require novel, alternative strategies to promote influenza vaccination. We developed “best practice” workflows with key stakeholders and end users and recognized the need for an organized processes system change, rather than individual change, which confirms other studies on the importance of collaboration and teamwork in process improvement. This standardized process substantially increased the number of perioperative vaccinations, particularly among Hispanic children, without increasing postoperative vaccine-related adverse events. Our intervention is sustainable and generalizable outside the COVID-19 pandemic. During the 2021 to 2022 influenza season, we had even greater success and vaccinated 3,166 patients perioperatively. While still a small percentage of the overall population presenting for anesthesia, we provided a reliable, expedited process with improved patient comfort to administer the influenza vaccine. Thus, our findings that the perioperative period is a novel healthcare opportunity to create a teachable moment and increase vaccination rates may have important implications for not only influenza vaccination, but also potentially for other childhood vaccinations, including COVID-19 vaccines.
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