Physician Briefing
Dementia risk did not differ by general, regional anesthesia in seniors undergoing elective surgery
Clive Velkers, from Queen’s University in Kingston, Ontario, Canada, and colleagues used linked administrative databases to identify community-dwelling individuals (≥66 years of age) who underwent one of five elective surgical procedures in Ontario, Canada, between April 1, 2007, and March 31, 2011. The analysis included 7,499 pairs of those undergoing GA and those receiving RA who were matched for age, sex, cohort entry year, and a propensity score.
The researchers found no difference in the risk for being diagnosed with dementia for individuals who received GA compared with RA (hazard ratio [HR], 1.0; 95 percent confidence interval, 0.8 to 1.2). Additionally, there was no association between anesthesia and dementia in most subgroup and sensitivity analyses.
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