METHODS: In this prospective validation intervention study, 20 healthy volunteers were breathing standardized oxygen concentrations ranging from mild hypoxia (fraction of inspired oxygen = 0.14) to hyperoxia (fraction of inspired oxygen = 1.0) via a tight-fitting face mask. ORi was measured noninvasively by multiwavelength pulse co-oximetry using 2 finger sensors. These ORi values (unitless scale, 0.00–1.00) were compared with measured Pao2 values. Repeated-measurements correlation analysis was performed to assess the ORi/Pao2 relationship. ORi trending ability was assessed using a 4-quadrant plot. The area under the receiver operating characteristics curve was calculated to assess the prediction of hypoxia (low-ranged Pao2, <100 mm Hg).
RESULTS: Within the ORi-sensitive range, a strong positive correlation was found between ORi and Pao2 for both sensors (R = 0.78 and 0.83; P < .0001). ORi trending of Pao2 was good within this range (concordance rate = 94%). The prediction of Pao2 <100 mm Hg was also good, with an area under the receiver operating characteristics curve of 0.91 and 99% sensitivity and 82% specificity.
CONCLUSIONS: In this prospective volunteer validation study, a strong and positive correlation between Pao2 and ORi was found, together with a good trending ability. Based on these data, the future use of ORi as a continuous noninvasive monitoring tool for assessing oxygenation status in patients receiving supplemental oxygen might be supported.
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