AUTHORS: Dardashti A et al
Acta Anaesthesiologica Scandinavica (Jul 2019)
METHODS This prospective, randomized, double-blind study included forty patients with normal cardiac and renal functions, who underwent coronary artery bypass grafting. One group received a prime based on Ringer’s acetate (n=20), and the other a prime consisting of Ringer’s acetate with 200 mL mannitol (n=20). Changes in osmolality, acid-base status, electrolytes and renal- related parameters were monitored.
RESULTS No significant differences were found in osmolality between the Ringer’s acetate group and the mannitol group at any time. The mannitol group showed a pronounced decrease in sodium, from 138.7±2.8 mmol/L at anesthesia onset, to 133.9±2.6 mmol/L after the start of CPB (p<0.001). No differences were seen in the renal parameters between the groups, apart from a short-term effect of mannitol on peroperative urine production (p = 0.003).
CONCLUSION We observed no effects on osmolality of a prime solution containing mannitol compared to Ringer’s acetate based prime in patients with normal cardiac and renal function. The use of mannitol in the prime resulted in a short-term, significant decrease in sodium level.