BACKGROUND Carbamazepine (CBZ) is the first-line therapy for Trigeminal Neuralgia (TGN), and Microvascular Decompression (MVD) is considered as an effective surgical treatment for TGN. But the effect of preoperative CBZ treatment for MVD outcome is not clear.
METHODS A total of 63 patients with classical TGN underwent MVD at the First Affiliated Hospital of Zhengzhou University, PR China, from 2013 to 2019. The data was collected through telephone follow-up and electronic medical records in April 2020, the short-term surgical outcome and the long-term follow-up data were estimated by univariate and multivariate analysis.
RESULTS The multivariate analysis result indicated that preoperative CBZ treatment history was not a significant predictor for short-term outcomes of Microvascular Decompression (P>0.05). The multivariate analysis result for the long-term outcome of MVD indicated that the medication history of preoperative CBZ treatment could predict its postoperative recurrence (P<0.05).
CONCLUSION For patients with classical TGN, a longer preoperative medication history of CBZ treatment had no significant effect on the short-term surgery outcome, but had a poor long-term outcome following MVD.