DG Journal Club
J Clin Anesth. 2022 Jul 2; 81 110918
STUDY OBJECTIVE The role of lidocaine patch (LP) in reducing postoperative pain by local anesthetic absorption has been evaluated in several studies; however, these trials have shown inconsistent results. This meta-analysis aimed to identify the benefits of LP, focusing on its pain-reducing and morphine-sparing effect in patients after surgery.
SETTING Published randomized controlled trials (RCTs) comparing the analgesic effects of LP after surgery to those of placebo or no patch.
PATIENTS Eleven RCTs including 539 patients.
INTERVENTIONS We searched electronic databases to identify relevant RCTs.
MEASUREMENTS The primary outcome was postoperative pain score up to 48B h assessed using a numerical rating or visual analog scale, and the secondary outcomes were postoperative morphine consumption and side effects. The effect size was estimated by calculating the mean difference (MD) or risk ratio (RR), with 95% confidence interval (CI).
MAIN RESULTS LP significantly decreased postoperative pain score at 6B h (MD, -1.85; 95% CI, -2.98 to -0.72; pB =B 0.001), 12B h (MD, -1.48; 95% CI, -2.07 to -0.88; pB
CONCLUSIONS LP can lower postoperative pain without side effects, compared to placebo or no patch. However, its morphine-sparing effect remains unclear.