Authors: Wei Zhang, M.D. et al
Anesthesiology 12 2016, Vol.125, 1251-1252.
In a prospective, randomized, and placebo-controlled trial, Lee et al.1 recently showed that administration of 20% exogenous albumin immediately before surgery increases urine output during surgery and reduces the risk of acute kidney injury (AKI) after off-pump coronary artery bypass surgery in patients with a preoperative serum albumin level of less than 4.0 g/dl. Many things in this study were done correctly. But to differentiate the effects of one factor on study endpoints, all the other factors have to be standardized in the study design. Several important factors in this study were not addressed well.